Huang Fang, Tang Lin-Hua, Yu Lin-Qian, Ni Yi-Chang, Wang Qin-Mei, Nan Fa-Jun
National Institute of Parasite Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China.
Biomed Environ Sci. 2006 Oct;19(5):367-70.
To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.
Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.
DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.
Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.
体外筛选瑞香素衍生物抗恶性疟原虫的化合物。
采用改良的Trager和Jensen方法体外培养恶性疟原虫（FCC1）。通过显微镜检测法和微量荧光法筛选抗疟化合物。
DA79和DA78对体外培养的恶性疟原虫显示出强效抗疟活性。
尽管瑞香素衍生物的结构与其抗疟活性之间的关系尚未阐明，但本研究可能为发现更多潜在抗疟化合物提供新方向。
