Watanabe-Sawaguchi K, Kubota K, Arikuni T
Department of Neurophysiology, Kyoto University, Aichi, Japan.
J Comp Neurol. 1991 Sep 1;311(1):108-33. doi: 10.1002/cne.903110109.
A study was made of the cytoarchitecture of the lateral and medial frontal cortex in the hamadryas baboon (Papio hamadryas). The frontal cortico-cortical connections of areas 46, 8, 6, and 4 were investigated by injection of wheat-germ agglutinine conjugated to horseradish peroxiase (WGA-HRP) into different regions of areas 46, 8, and 6. The lateral region of the frontal lobe of the baboon consists of broad areas of motor (area 4), premotor (area 6), and the dorsolateral prefrontal cortex, each of which is further divided into subdivisions with distinct cytoarchitectural features: areas 4a, 4b, 4c; 6 a alpha, 6a beta, 6a gamma, and 6b beta; 8A and 8B; 45; 46 and 46ps; 9; 10; and 12. Although the frontal cortex of the baboon brain exhibits the same basic cytoarchitectural features as the frontal corticies of the cercopithecus (campbelli?) (Vogt and Vogt, '19) or the macaque (Walker, '40; Barbas and Pandya, '87, '89), the baboon frontal cortex is very different from that of the macaque and cercopithecus in terms of cytoarchitecture: (1) the baboon frontal cortex has an additional area, termed here "6a gamma", within area 6, which has cytoarchitectural characteristics that are intermediate between those of areas 6 and 8; (2) the aggregation of giant pyramidal cells (greater than 50 microns in diameter) is found only in area 4a in the baboon, whereas such aggregates are found in areas 4a and 4b and, occasionally, in area 4c in the macaque; and (3) area 46 of the prefrontal cortex of the baboon can be subdivided into the cortex that surrounds the principal sulcus (area 46) and the upper and lower banks of the principal sulcus (area 46ps). Retrogradely WGA-HRP labeled cells and anterogradely WGA-HRP labeled terminals coexisted in the frontal cortex in a columnar fashion, indicative of a reciprocity among the connections. The frontal cortico-cortical connections of areas 46, 8, 6, and 4 in the hamadryas baboon were organized as follows: (1) areas 46, 8, and 6 were connected to one another, (2) area 4 was connected only to area 6, and (3) these connections showed a gross ventrodorsal topography: the ventral regions of each of areas 46, 8, and 6 were connected more strongly to the ventral than the dorsal regions of the other areas; the dorsal regions of each of areas 46, 8, and 6 were connected more strongly to the dorsal than the ventral regions of the other areas.(ABSTRACT TRUNCATED AT 400 WORDS)
对阿拉伯狒狒（Papio hamadryas）额叶外侧和内侧皮质的细胞结构进行了研究。通过将与辣根过氧化物酶结合的小麦胚芽凝集素（WGA-HRP）注射到46区、8区和6区的不同区域，研究了46区、8区、6区和4区的额叶皮质-皮质连接。狒狒额叶外侧区域由运动区（4区）、运动前区（6区）和背外侧前额叶皮质的广阔区域组成，每个区域又进一步细分为具有不同细胞结构特征的亚区：4a区、4b区、4c区；6aα区、6aβ区、6aγ区和6bβ区；8A区和8B区；45区；46区和46ps区；9区；10区；以及12区。尽管狒狒大脑的额叶皮质表现出与猕猴（坎贝尔猕猴？）（沃格特和沃格特，19年）或猕猴（沃克，40年；巴巴斯和潘迪亚，87年、89年）的额叶皮质相同的基本细胞结构特征，但狒狒额叶皮质在细胞结构方面与猕猴和猕猴有很大不同：（1）狒狒额叶皮质在6区内有一个额外的区域，这里称为“6aγ区”，其细胞结构特征介于6区和8区之间；（2）仅在狒狒的4a区发现巨型锥体细胞（直径大于50微米）的聚集，而在猕猴的4a区和4b区以及偶尔在4c区发现这种聚集；（3）狒狒前额叶皮质的46区可细分为围绕主沟的皮质（46区）和主沟的上下缘（46ps区）。逆行WGA-HRP标记的细胞和顺行WGA-HRP标记的终末以柱状方式共存于额叶皮质中，表明连接之间存在相互性。阿拉伯狒狒46区、8区、6区和4区的额叶皮质-皮质连接如下组织：（1）46区、8区和6区相互连接，（2）4区仅与6区连接，（3）这些连接呈现出大致的腹背拓扑结构：46区、8区和6区的每个区域的腹侧区域与其他区域的腹侧区域的连接比与背侧区域的连接更强；46区、8区和6区的每个区域的背侧区域与其他区域的背侧区域的连接比与腹侧区域的连接更强。（摘要截断于400字）
