Kralovec J A, Metera K L, Kumar J R, Watson L V, Girouard G S, Guan Y, Carr R I, Barrow C J, Ewart H S
Ocean Nutrition Canada Ltd., 101 Research Drive, Dartmouth, NS, B2Y 4T6.
Phytomedicine. 2007 Jan;14(1):57-64. doi: 10.1016/j.phymed.2005.09.002. Epub 2005 Nov 2.
Our proprietary preparation obtained by extraction of Chlorella pyrenoidosa cells, ONC-107 (Respondin), was recently found to selectively boost antibody response to the influenza vaccine in a human clinical trial. Respondin is a potent stimulator of mouse B cell proliferation and an activator of macrophages. Bioactivity-guided resolution concluded that Respondin is composed of a mixture of immunostimulatory principles of different chemical nature. A combination of size exclusion, anion exchange and hydrophobic interaction chromatography revealed that the bulk of the immunostimulatory activity resides in polysaccharide/protein complexes with molecular masses larger than 100 kDa that are composed primarily of galactose, rhamnose and arabinose.
