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1例转移性无性细胞瘤患者，先行2周期新辅助化疗，随后接受保留生育功能的微创手术治疗。

A case of metastatic dysgerminoma treated with two cycles neoadjuvant chemotherapy followed by fertility-sparing minimally invasive surgery.

作者信息

Eurich Katrin E, Swisher Elizabeth, Toukatly Mirna, Koch Lisa, Wu Emily S

机构信息

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA 98195, USA.

Department of Pathology, University of Washington, 1959 NE Pacific Street, Box 357470, Seattle, WA 98195, USA.

出版信息

Gynecol Oncol Rep. 2019 Apr 6;28:124-127. doi: 10.1016/j.gore.2019.04.003. eCollection 2019 May.

DOI:10.1016/j.gore.2019.04.003
PMID:31024985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6476800/
Abstract

•Neoadjuvant chemotherapy (NACT) followed by fertility-sparing surgery is a feasible treatment of metastatic dysgerminoma•As few as two cycles of NACT may result in enough of a tumor response for fertility-sparing surgery to be possible.•Tumor lysis syndrome is a possibility when administering chemotherapy to patients with metastatic dysgerminoma.

摘要

•新辅助化疗（NACT）后行保留生育功能手术是转移性无性细胞瘤的一种可行治疗方法。

•NACT仅两个周期就可能产生足够的肿瘤反应，使保留生育功能手术成为可能。

•对转移性无性细胞瘤患者进行化疗时，有可能发生肿瘤溶解综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/cdf233929f55/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/87ef18dc723a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/93e5a3ba2078/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/e3a791804717/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/cdf233929f55/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/87ef18dc723a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/93e5a3ba2078/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/e3a791804717/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde2/6476800/cdf233929f55/gr4.jpg

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本文引用的文献

1
Malignant ovarian germ cell tumor - role of surgical staging and gonadal dysgenesis.恶性卵巢生殖细胞肿瘤-手术分期和性腺发育不良的作用。
Gynecol Oncol. 2014 Jul;134(1):84-9. doi: 10.1016/j.ygyno.2014.05.003. Epub 2014 May 14.
2
Neo-adjuvant chemotherapy in the treatment of advanced malignant germ cell tumors of ovary.新辅助化疗治疗晚期卵巢恶性生殖细胞肿瘤。
Gynecol Oncol. 2014 Jan;132(1):28-32. doi: 10.1016/j.ygyno.2013.10.009. Epub 2013 Oct 19.
3
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution.
在恶性卵巢生殖细胞肿瘤的初次治疗失败中，挽救性手术后的残留肿瘤是主要的危险因素：单中心回顾性研究。
World J Surg Oncol. 2011 Oct 11;9:123. doi: 10.1186/1477-7819-9-123.
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Outcome and prognostic factors in ovarian germ cell malignancies.卵巢生殖细胞恶性肿瘤的结局及预后因素
Gynecol Oncol. 2005 Mar;96(3):784-91. doi: 10.1016/j.ygyno.2004.11.027.
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Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: an intergroup study.儿童及青少年卵巢恶性生殖细胞肿瘤的结局与分期评估：一项多组间研究
J Pediatr Surg. 2004 Mar;39(3):424-9; discussion 424-9. doi: 10.1016/j.jpedsurg.2003.11.027.
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Acute tumor lysis syndrome in solid tumors--a case report and review of the literature.实体瘤中的急性肿瘤溶解综合征——一例病例报告及文献综述
Cancer Chemother Pharmacol. 2003 Mar;51(3):187-92. doi: 10.1007/s00280-002-0556-x. Epub 2003 Feb 28.
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Equivalence of three or four cycles of bleomycin, etoposide, and cisplatin chemotherapy and of a 3- or 5-day schedule in good-prognosis germ cell cancer: a randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group and the Medical Research Council.博来霉素、依托泊苷和顺铂三或四个周期化疗与3天或5天疗程在预后良好的生殖细胞癌中的等效性：欧洲癌症研究与治疗组织泌尿生殖系统癌症合作组和医学研究理事会的一项随机研究
J Clin Oncol. 2001 Mar 15;19(6):1629-40. doi: 10.1200/JCO.2001.19.6.1629.
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Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. A review of 74 cases.保留恶性卵巢生殖细胞肿瘤患者卵巢功能的保守性手术。74例病例回顾。
Cancer. 2000 Jul 15;89(2):391-8.
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