一种作为酿酒酵母液泡型H⁺-ATP酶抑制剂的新型 destruxin。

A new destruxin as inhibitor of vacuolar-type H+-ATPase of Saccharomyces cerevisiae.

作者信息

Vázquez María J, Albarrán María I, Espada Alfonso, Rivera-Sagredo Alfonso, Díez Emilio, Hueso-Rodríguez Juan A

机构信息

Assay Development and Compound Profiling Department, GlaxoSmithKline, R&D, Centro de Investigación Básica, Santiago Grisolía 4, E-28760 Tres Cantos, Madrid.

出版信息

Chem Biodivers. 2005 Jan;2(1):123-30. doi: 10.1002/cbdv.200490163.

DOI:10.1002/cbdv.200490163

PMID:17191925

Abstract

In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H+-ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1-8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D- and 2D-NMR spectroscopy, and MS spectrometry. One of these compounds, 8, a regioisomer of chlorohydrin destruxin E (7), is a new destruxin.

摘要

在我们筛选能够作为酿酒酵母液泡型H⁺-ATP酶选择性抑制剂的小分子的过程中，我们从绿僵菌中鉴定出了8种活性环肽毒素1 - 8。通过广泛的一维和二维核磁共振光谱以及质谱对其结构进行了阐明。其中一种化合物8，是氯醇环肽毒素E（7）的区域异构体，是一种新的环肽毒素。