Cai P, Smith D, Katz B, Pearce C, Venables D, Houck D
MYCOsearch, OSI Pharmaceuticals, Durham, North Carolina 27707, USA.
J Nat Prod. 1998 Feb;61(2):290-3. doi: 10.1021/np970475c.
In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 microM.
在筛选促红细胞生成素基因表达的小分子调节剂过程中，从OS-F68576真菌培养物中分离出5种环缩肽。通过广泛的1H和13C核磁共振光谱以及水解修饰确定了其结构。一种化合物（环缩肽-A4氯醇，1）是一种新型环缩肽。所有这些化合物在浓度为0.2 - 2 microM时可诱导促红细胞生成素基因表达增加5倍。
