Zhang Yu-Mei, Tan Ning-Hua, Yang Ya-Bin, Lu Yang, Cao Peng, Wu Yun-Shan
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650204 Kunming, Yunnan, People's Republic of China.
Chem Biodivers. 2005 Apr;2(4):497-505. doi: 10.1002/cbdv.200590030.
Six new norlignans, named sequosempervirins B-G (1-6), together with three known norlignans, agatharesinol (7), agatharesinol acetonide (8), and sugiresinol (9), were isolated from the branches and leaves of Sequoia sempervirens. Their structures were determined mainly by high-resolution mass spectroscopy (HR-MS), and various 1D- and 2D-NMR methods, as well as, in the case of 1, by means of X-ray diffraction. Compound 8 showed anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM). The acetone extract of S. sempervirens was found to be antifungal towards Candida glabrata (IC50 = 15.98 microg/ml), and both the acetone and MeOH extracts inhibited the proteolytic activity of cathepsin B (IC50 = 4.58 and 5.49 microg/ml, resp.).
从红杉的枝叶中分离出6个新的降木脂素，命名为红杉恒生素B - G（1 - 6），以及3个已知的降木脂素，即贝壳杉树脂醇（7）、贝壳杉树脂醇丙酮化物（8）和杉树脂醇（9）。它们的结构主要通过高分辨率质谱（HR-MS）、各种一维和二维核磁共振方法确定，其中化合物1还通过X射线衍射确定。化合物8对A549非小细胞肺癌细胞系显示出抗癌活性（IC50 = 27.1 microM）。发现红杉的丙酮提取物对光滑念珠菌具有抗真菌作用（IC50 = 15.98 microg/ml），丙酮提取物和甲醇提取物均能抑制组织蛋白酶B的蛋白水解活性（IC50分别为4.58和5.49 microg/ml）。
