来自北美红杉球果的抗肿瘤枞酸型二萜类化合物。

Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens.

作者信息

Son Kwang-Hee, Oh Hyun-Mi, Choi Sung-Kyu, Han Dong Cho, Kwon Byoung-Mog

机构信息

Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 52 Uendong Yoosunggu Taejeon, 305-600 Republic of Korea.

出版信息

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2019-21. doi: 10.1016/j.bmcl.2005.02.057.

DOI:10.1016/j.bmcl.2005.02.057

PMID:15808460

Abstract

A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6alpha-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI(50) 2-5 microg/mL.

摘要

从红杉球果中分离出一种新的枞酸型二萜，即20-羟基铁锈醇（1），以及已知的铁锈醇（2）、18-羟基铁锈醇（3）、苏乔醇（4）和6α-羟基苏乔醇（5）。通过光谱数据阐明了它们的结构。化合物1和5对人结肠癌、肺癌和乳腺癌以及癌基因转化细胞具有强烈的抑制作用，其半数生长抑制浓度（GI(50)）为2-5微克/毫升。