Chaubal Rohini, Pawar Pushpa V, Hebbalkar Geeta D, Tungikar Vijay B, Puranik Vedavati G, Deshpande Vishnu H, Deshpande Nirmala R
T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parshurambhau College, 411 030 Pune, Maharashtra, India.
Chem Biodivers. 2005 May;2(5):684-8. doi: 10.1002/cbdv.200590044.
A low-molecular-weight, sugar-like compound other than glucose, fructose, sucrose, or myo-inositol showing lipophilic nature was isolated from the EtOH extract of Acacia nilotica. The structure of the compound was determined by spectral methods. This alicyclic polyalcohol was found to be D-pinitol (= 3-O-methyl-D-chiro-inositol; 1). The configuration of the compound was confirmed by single-crystal X-ray analysis. The compound 1 is known from Soybean, Australian mangroves, Fagonia indica, Arachis hypogaea, etc., but we have isolated this compound for the first time from the aerial parts of A. nilotica. Very few references have been cited for compound 1 for its entomological activity, and there are no reports on mosquitoes. Therefore, the crude extracts of A. nilotica were tested for its biological activity against mosquito larvae. Acetone extract at 500-ppm concentration showed chronic toxicity against Aedes aegypti and Culex quinquefasciatus IVth instar mosquito larvae. Such a biological activity has been observed for the first time for this plant. This study could be a stepping stone to a solution for destroying larval species as well as consumption of such a widely grown, problem weed, A. nilotica. This larvicidal agent, since it is derived from plant, is eco-friendly, cost effective, non-hazardous to non-target organisms and would be safe unlike commercially available insecticides.
从阿拉伯胶树的乙醇提取物中分离出一种除葡萄糖、果糖、蔗糖或肌醇之外的具有亲脂性的低分子量类糖化合物。通过光谱方法确定了该化合物的结构。这种脂环族多元醇被发现是D-松醇（= 3-O-甲基-D-手性肌醇；1）。通过单晶X射线分析证实了该化合物的构型。化合物1在大豆、澳大利亚红树林、硬直法戈尼亚、落花生等植物中已有记载，但我们首次从阿拉伯胶树的地上部分分离出该化合物。关于化合物1的昆虫学活性，引用的参考文献很少，且尚无关于蚊子的报道。因此，对阿拉伯胶树的粗提物进行了抗蚊幼虫生物活性测试。浓度为500 ppm的丙酮提取物对埃及伊蚊和致倦库蚊四龄幼虫显示出慢性毒性。这种植物首次观察到这种生物活性。这项研究可能是解决幼虫物种问题以及消耗这种广泛生长的有害杂草——阿拉伯胶树的一个垫脚石。这种杀幼虫剂由于源自植物，对环境友好、成本效益高、对非目标生物无害，且与市售杀虫剂不同，是安全的。
