Bennett A H, Carpenter A J, Barada J H
Division of Urological Surgery, Albany Medical Center, New York.
J Urol. 1991 Dec;146(6):1564-5. doi: 10.1016/s0022-5347(17)38167-3.
Papaverine hydrochloride (smooth muscle relaxant), phentolamine mesylate (alpha-adrenergic blocking agent) and prostaglandin E1 (vasodilator and smooth muscle relaxant) were combined to produce a potent vasoactive drug therapy for use in a pharmacological erection program. Doses of 2.5 cc papaverine (30 mg./cc), 0.5 cc phentolamine (5 mg./cc), 0.05 cc prostaglandin E1 (500 micrograms./cc) and 1.2 cc 0.9% normal saline were combined to produce a vial of 4.25 cc for patient convenience. Twenty unit vials were made from the 1 cc vial of prostaglandin E1, the most expensive ingredient. The solution is physiologically active for at least 6 months and can be stored at room temperature although refrigeration is recommended. The pH of the solution is 4. This vasoactive drug combination has been used in 116 patients for diagnostic testing and subsequent treatment. A dose of 0.25 cc has been effective for diagnosis and treatment in the majority of patients with mild to moderate arteriogenic and/or venogenic and diabetic impotence. For patients with neurogenic dysfunction 0.1 to 0.125 cc was the usual dose. Two patients had a prolonged erection requiring irrigation, 1 on the day of initial testing and 1 on home therapy. Pain at the site of injection or during intercourse was noted in only 2 patients and to date no fibrosis or plaques have been found.
盐酸罂粟碱（平滑肌松弛剂）、甲磺酸酚妥拉明（α-肾上腺素能阻滞剂）和前列腺素E1（血管扩张剂和平滑肌松弛剂）联合使用，产生一种强效血管活性药物疗法，用于药理学勃起方案。将2.5毫升罂粟碱（30毫克/毫升）、0.5毫升酚妥拉明（5毫克/毫升）、0.05毫升前列腺素E1（500微克/毫升）和1.2毫升0.9%生理盐水混合，制成4.25毫升的小瓶，方便患者使用。从1毫升前列腺素E1小瓶（最昂贵的成分）中制备了20个单位小瓶。该溶液至少6个月内具有生理活性，尽管建议冷藏，但可在室温下储存。溶液的pH值为4。这种血管活性药物组合已用于116例患者的诊断测试和后续治疗。0.25毫升的剂量对大多数轻度至中度动脉源性和/或静脉源性及糖尿病性阳痿患者的诊断和治疗有效。对于神经功能障碍患者，通常剂量为0.1至0.125毫升。两名患者出现持续性勃起需要冲洗，1例在初次测试当天，1例在家庭治疗期间。仅2例患者出现注射部位或性交时疼痛，迄今为止未发现纤维化或斑块。
