Mastorakos George, Ilias Ioannis
Second Department of Obstetrics and Gynecology, University of Athens, Greece.
Ann N Y Acad Sci. 2006 Nov;1088:373-81. doi: 10.1196/annals.1366.021.
The hypothalamic-pituitary-adrenal (HPA) axis and the proinflammatory cytokines (and interleukin-6 [IL-6] in particular) are enmeshed in the response to somatic stress, either in health or in acute or chronic disease. Usually IL-6 is elevated in states of septic (such as sepsis) or aseptic inflammation (such as rheumatoid arthritis). Exercise is a form of somatic stress. Local tissue IL-6 elevation is noted during shorter and less intense exercise, whereas brief peripheral IL-6 "bursts" are observed with longer and more intense exercise. Therapeutic interventions that target IL-6 or its soluble receptor are currently assessed, with an emphasis on autoimmune diseases and inflammatory conditions.
下丘脑-垂体-肾上腺（HPA）轴和促炎细胞因子（尤其是白细胞介素-6 [IL-6]）参与了机体对躯体应激的反应，无论是在健康状态下，还是在急性或慢性疾病中。通常，在脓毒症（如败血症）或无菌性炎症（如类风湿性关节炎）状态下，IL-6会升高。运动是躯体应激的一种形式。在较短且强度较小的运动过程中，会出现局部组织IL-6升高，而在较长且强度较大的运动中，则会观察到外周IL-6的短暂 “爆发”。目前正在评估针对IL-6或其可溶性受体的治疗干预措施，重点是自身免疫性疾病和炎症性疾病。
