Di Garbo Angelo, Barbi Michele, Chillemi Santi, Alloisio Susanna, Nobile Mario
Istituto di Biofisica CNR, Via G. Moruzzi 1, 56124 Pisa, Italy.
Biosystems. 2007 May-Jun;89(1-3):74-83. doi: 10.1016/j.biosystems.2006.05.013. Epub 2006 Nov 12.
Starting from the experimental data on ATP evoked calcium responses in astrocytes, a biophysical model describing these phenomena was built. The simulations showed, in agreement with the experimental findings, that the intracellular calcium fluxes mediated by the P2X and P2Y purinoreceptors are responsible for the biphasic ATP evoked calcium response in astrocytes. Then, the modulation effects on the neural dynamics arising from the release of glutamate from astrocyte are also investigated. By using a minimal network model describing a neuron coupled to the astrocyte, we demonstrated that the calcium extrusion rate through the astrocyte membrane is critically involved in the generation of different firing patterns of the neuron.
从星形胶质细胞中ATP诱发钙反应的实验数据出发，构建了一个描述这些现象的生物物理模型。模拟结果与实验结果一致，表明由P2X和P2Y嘌呤受体介导的细胞内钙通量是星形胶质细胞中ATP诱发双相钙反应的原因。然后，还研究了星形胶质细胞释放谷氨酸对神经动力学的调节作用。通过使用一个描述与星形胶质细胞耦合的神经元的最小网络模型，我们证明了通过星形胶质细胞膜的钙外排速率在神经元不同放电模式的产生中起着关键作用。
