Song Joon Young, Ha Seok Hoon, Kee Sae Yoon, Jeong Hye Won, Cheong Hee Jin, Kim Woo Joo
Division of Infectious Diseases, Department of Internal Medicine, Korea University, Seoul, Republic of Korea.
J Clin Virol. 2007 Feb;38(2):149-52. doi: 10.1016/j.jcv.2006.08.022. Epub 2006 Dec 29.
Influenza vaccination is the primary method for preventing influenza and its severe complications. Healthcare workers (HCWs) are one of the priority groups for the influenza vaccination.
To determine whether healthy HCWs, who were vaccinated with the same subtype for the two previous years, could be given less priority for influenza immunization under the vaccine shortage.
We measured hemagglutination-inhibition antibody titers from sequential serum samples in 50 pre-immune subjects and 50 age-matched vaccine-naive subjects: immediately prior to the administration of the vaccine, 4-6 weeks, and 6 months after the vaccination.
Prevaccination titers were maintained above protective level and high protection rates were observed for all three strains in pre-immune subjects: A/H1N1, A/H3N2, and B strains. As for the sequential changes, the protection rates for all three strains still remained above 70% until 6 months following the vaccination.
Skipping influenza vaccination for a year could be considered in healthy pre-immune HCWs under the epidemic of the same subtype as two previous years.
流感疫苗接种是预防流感及其严重并发症的主要方法。医护人员是流感疫苗接种的优先群体之一。
确定在疫苗短缺情况下，前两年接种相同亚型疫苗的健康医护人员是否可以降低流感免疫接种的优先级。
我们检测了50名未免疫受试者和50名年龄匹配的未接种疫苗受试者连续血清样本中的血凝抑制抗体滴度：在接种疫苗前、接种后4 - 6周以及接种后6个月。
在未免疫受试者中，针对甲型H1N1、甲型H3N2和乙型这三种毒株，接种前滴度维持在保护水平以上，且观察到高保护率。至于连续变化情况，接种后6个月内，这三种毒株的保护率仍保持在70%以上。
在与前两年相同亚型流行的情况下，对于健康的已产生免疫的医护人员，可以考虑跳过一年的流感疫苗接种。
