Colfax Grant Nash, Vittinghoff Eric, Grant Robert, Lum Paula, Spotts Gerald, Hecht Frederick M
AIDS Office, San Francisco Department of Public Health, San Francisco, California, USA.
AIDS. 2007 Jan 11;21(2):239-41. doi: 10.1097/QAD.0b013e3280114a29.
We determined whether methamphetamine use is associated with the increased prevalence of primary HIV drug resistance among a cohort of men who have sex with men recently infected with HIV. In multivariate analysis, we found that frequent methamphetamine use was strongly associated with primary non-nucleoside reverse transcriptase inhibitor resistance, but not with protease inhibitor or nucleoside reverse transcriptase inhibitor resistance. We postulate that this association may be caused by methamphetamine-associated treatment interruptions among source partners.
我们确定了在一群近期感染艾滋病毒的男男性行为者中，使用甲基苯丙胺是否与原发性艾滋病毒耐药性患病率增加有关。在多变量分析中，我们发现频繁使用甲基苯丙胺与原发性非核苷类逆转录酶抑制剂耐药性密切相关，但与蛋白酶抑制剂或核苷类逆转录酶抑制剂耐药性无关。我们推测这种关联可能是由传染源伙伴中与甲基苯丙胺相关的治疗中断引起的。
