von Geldern Gloria, Cepok Sabine, Nolting Thorsten, Du Yihua, Grummel Verena, Adams Ortwin, Hartung Hans-Peter, Arendt Gabriele, Hemmer Bernhard
Department of Neurology, Germany.
AIDS. 2007 Jan 11;21(2):250-3. doi: 10.1097/QAD.0b013e328011ec76.
Central nervous system involvement is common in HIV infection. We determined the relationship between T-cell subsets and viral load in the cerebrospinal fluid (CSF) of therapy-naive, asymptomatic HIV-infected individuals. A shift from naive to effector-memory CD8 T cells was observed in the CSF of HIV-infected individuals compared with controls. The HIV load strongly correlated with CD8 T cells in CSF. Effector-memory CD8 T cells were positively and effector CD8 T cells were negatively associated with viral replication in CSF.
中枢神经系统受累在HIV感染中很常见。我们确定了初治、无症状HIV感染个体脑脊液（CSF）中T细胞亚群与病毒载量之间的关系。与对照组相比，在HIV感染个体的脑脊液中观察到从初始CD8 T细胞向效应记忆CD8 T细胞的转变。HIV载量与脑脊液中的CD8 T细胞密切相关。效应记忆CD8 T细胞与脑脊液中的病毒复制呈正相关，而效应CD8 T细胞与脑脊液中的病毒复制呈负相关。
