Underdahl N R, Mebus C A, Torres-Medina A
Am J Vet Res. 1975 Oct;36(10):1473-6.
Transmissible gastroenteritis (TGE) virus was reisolated from pulmonary and intestinal tissues from 6 of 9 chronically infected experimental pigs (principals) necropsied 30 to 104 days after inoculation. Tissue homogenates (lung and small intestine) from the principals were prepared and inoculated into 3- to 5-day-old gnotobiotic pigs. The virus reisolated from the tissue homogenates produced a milder disease on 1st passage and a more severe disease on 2nd passage. The chronically infected experimental pigs (principals) developed serum-neutralization titers to TGE of 1:30 to 1:525. There appeared to be no relationship between serum titers and reisolation of TGE virus from the 9 principals. The persistence of virus in lung or intestine to 104 days indicates the recovered (or carrier) pig may be considered the primary source of TGE virus infection.
从接种后30至104天剖检的9头慢性感染实验猪（主要病例）中的6头的肺和肠道组织中重新分离出了传染性胃肠炎（TGE）病毒。制备了主要病例的组织匀浆（肺和小肠）并接种到3至5日龄的无菌猪中。从组织匀浆中重新分离出的病毒在第1代传代时引起较轻微的疾病，在第2代传代时引起更严重的疾病。慢性感染的实验猪（主要病例）产生的针对TGE的血清中和滴度为1:30至1:525。血清滴度与从9头主要病例中重新分离出TGE病毒之间似乎没有关系。病毒在肺或肠道中持续存在至104天，这表明康复猪（或携带病毒的猪）可能被视为TGE病毒感染的主要来源。
