Lam Andrew K C, Chen Davie
School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Cornea. 2007 Jan;26(1):55-8. doi: 10.1097/01.ico.0000240082.08416.22.
To study the effect of 1 drop of 0.5% proparacaine on central corneal thickness values monitored by nonspecular microscopy and Pentacam, a corneal topographer with rotating Scheimpflug camera.
Forty subjects were divided into 2 groups with 1 group measured with a noncontact specular microscope and the other group with Pentacam (Oculus, Inc., Wetzlar, Germany). One eye was randomly selected, and corneal thickness values were monitored every 30 seconds for 10 minutes. Baseline corneal thickness values were defined as the average of all measurements taken over 10 minutes. One drop of 0.5% proparacaine was instilled, and the corneal thickness values were monitored by the same instrument every 30 seconds for another 10 minutes after drug instillation.
The 2 groups shared similar age range, refractive error, and baseline corneal thickness values. The spontaneous variation of corneal thickness values was within 3 mum for 10 minutes before drug instillation. There was no obvious trend of corneal thickness value change after the instillation of local anesthetics. The variation of corneal thickness values against the baseline was within 5 mum.
One drop of 0.5% proparacaine does not produce any significant change in central corneal thickness.
研究一滴0.5%丙美卡因对通过非镜面显微镜和Pentacam（一种配备旋转式Scheimpflug相机的角膜地形图仪）监测的中央角膜厚度值的影响。
40名受试者被分为两组，一组用非接触式镜面显微镜测量，另一组用Pentacam（德国韦茨拉尔的Oculus公司）测量。随机选择一只眼睛，每30秒监测一次角膜厚度值，持续10分钟。基线角膜厚度值定义为10分钟内所有测量值的平均值。滴入一滴0.5%丙美卡因，用药后再用同一仪器每30秒监测一次角膜厚度值，持续10分钟。
两组的年龄范围、屈光不正和基线角膜厚度值相似。用药前10分钟角膜厚度值的自发变化在3μm以内。局部麻醉药滴入后角膜厚度值没有明显的变化趋势。与基线相比，角膜厚度值的变化在5μm以内。
一滴0.5%丙美卡因不会使中央角膜厚度产生任何显著变化。
