Yliskoski M, Saarikoski S, Syrjänen K
Department of Obstetrics and Gynecology/3302, Kuopio University Central Hospital, Finland.
Arch Gynecol Obstet. 1991;249(2):59-65. doi: 10.1007/BF02390363.
We report results of follow-up by PAP smears and colposcopy in 116 women treated since 1981 by conization for cervical intraepithelial neoplasia with human papillomavirus infection (HPV-CIN). The mean follow-up time was 31.9 (SD 19) months. Preoperative diagnosis was HPV-CIN II (with extension into the endocervix) in 11 cases and HPV-CIN III in 103 cases; two diagnostic conizations were performed. The histological examination of the cone biopsies showed complete excision of CIN in 109 cases (94%). Three patients underwent hysterectomy after conization; one had microinvasion in the cone biopsy, one had suspicion of microinvasion and one had non-radical conization. Three patients (2.6%) were lost to follow-up. After excluding these six patients the primary cure rate of HPV lesions (normal cytological and colposcopical finding after conization) was 82.7%. Four patients (4.6%) had residual CIN after conization. During the follow-up 15 patients had recurrence of HPV infection, only one had HPV-CIN I. HPV 16 was the most common HPV type (56/116, 48.2%) in the conization group and also in the recurrent cases (9/15, 60%). The results support the role of HPV 16 in cervical carcinogenesis.
我们报告了自1981年以来接受宫颈锥切术治疗的116例人乳头瘤病毒感染的宫颈上皮内瘤变（HPV-CIN）患者的巴氏涂片和阴道镜随访结果。平均随访时间为31.9（标准差19）个月。术前诊断为HPV-CIN II（累及宫颈管）11例，HPV-CIN III 103例；进行了2次诊断性锥切术。锥切活检的组织学检查显示109例（94%）CIN被完全切除。3例患者在锥切术后接受了子宫切除术；1例锥切活检有微浸润，1例怀疑有微浸润，1例锥切不彻底。3例患者（2.6%）失访。排除这6例患者后，HPV病变的初次治愈率（锥切术后细胞学和阴道镜检查结果正常）为82.7%。4例患者（4.6%）锥切术后有残留CIN。随访期间15例患者HPV感染复发，仅1例为HPV-CIN I。HPV 16是锥切组以及复发病例中最常见的HPV类型（56/116，48.2%）（9/15，60%）。这些结果支持HPV 16在宫颈癌发生中的作用。
