Hald Tine, Wingstrand Anne, Brøndsted Therese, Lo Fo Wong Danilo Marino Armando
Danish Zoonosis Centre, Danish Institute for Food and Veterinary Research, Søborg, Denmark.
Foodborne Pathog Dis. 2006 Winter;3(4):422-31. doi: 10.1089/fpd.2006.3.422.
The objectives of our study were to estimate the number of reported cases of human salmonellosis in Denmark that can be attributed to the occurrence of Salmonella in soy-based animal feed and to assess whether certain serotypes can be considered of less importance to human health. The assessment was based on a comparison of Salmonella serotypes isolated from feedstuffs, swine, cattle, and humans, primarily collected through the Danish Salmonella surveillance programs, supplemented with international data sources. The results are presented in three different forms: a qualitative assessment of all serotypes isolated from animal feed and/or food-producing animals based on their detection in humans; a semiquantitative ranking of serotypes by the apparent differences in their public health impact; and an estimate of the number of reported cases of human salmonellosis that can be attributed to the occurrence of Salmonella in soy-based animal feed. Salmonella isolates included in this study belonged to 91 distinct serotypes. Of the 82 serotypes found in both production animals and humans, 45 were also found in feed. In the period from 1999 to 2003, 14.4% of reported human infections were caused by serotypes also isolated from animal feed. Based on a modified version of a previously published risk model, we estimated that up to 1.7% of the total number of reported human cases and 2.1% of domestically acquired infections in the period 1999-2003 could be attributed to feedborne serotypes acquired through the consumption of Danish pork and beef. We concluded that more than 90% of serotypes have the potential, if they occur in feedstuffs, for infecting humans via production animals or foods of animal origin.
我们研究的目的是估计丹麦报告的人类沙门氏菌病病例数中可归因于大豆基动物饲料中沙门氏菌存在的病例数，并评估某些血清型是否可被认为对人类健康不太重要。该评估基于对主要通过丹麦沙门氏菌监测计划收集的、并辅以国际数据源的饲料、猪、牛和人类中分离出的沙门氏菌血清型进行比较。结果以三种不同形式呈现：基于在人类中检测到的情况对从动物饲料和/或食用动物中分离出的所有血清型进行定性评估；根据血清型对公共卫生影响的明显差异进行半定量排名；以及估计可归因于大豆基动物饲料中沙门氏菌存在的人类沙门氏菌病报告病例数。本研究中纳入的沙门氏菌分离株属于91种不同血清型。在生产动物和人类中均发现的82种血清型中，有45种也在饲料中发现。在1999年至2003年期间，报告的人类感染病例中有14.4%是由也从动物饲料中分离出的血清型引起的。基于之前发表的风险模型的修改版本，我们估计在1999 - 2003年期间，报告的人类病例总数的1.7%以及国内获得性感染的2.1%可归因于通过食用丹麦猪肉和牛肉获得的食源性血清型。我们得出结论，如果血清型出现在饲料中，超过90%的血清型有可能通过生产动物或动物源性食品感染人类。
