Prezioso Domenico, Denis Louis J, Klocker Helmut, Sciarra Alexandria, Reis Mario, Naber Kurt, Lobel Bernard, Pacik Dalibor, Griffiths Keith
Oncology Center, Antwerpen, Belgium.
Int J Urol. 2007 Jan;14(1):1-16. doi: 10.1111/j.1442-2042.2006.01476.x.
Estrogens have long been associated with the processes involved in prostate carcinogenesis, particularly in cancer suppression. However, the synergistic influence of low concentrations of estrogens, together with androgens, in promoting aberrant growth of the gland has also been recognized. As new insights into the complex molecular events implicated in growth regulation of the prostate are revealed, the role of the estrogens has become clearer. The present review considers this role in relation to the pathogenesis of prostate cancer and the potential cancer-repressive influence of the dietary estrogens.
长期以来，雌激素一直与前列腺癌发生过程相关，尤其是在癌症抑制方面。然而，低浓度雌激素与雄激素协同促进前列腺异常生长的影响也已得到认可。随着对前列腺生长调节中涉及的复杂分子事件有了新的认识，雌激素的作用变得更加清晰。本综述探讨了雌激素在前列腺癌发病机制中的作用以及膳食雌激素潜在的癌症抑制作用。
