Kalivas Peter W, Peters Jamie, Knackstedt Lori
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29464, USA.
Mol Interv. 2006 Dec;6(6):339-44. doi: 10.1124/mi.6.6.7.
Animal models in the field of addiction are considered to be among the best available models of neuropsychiatric disease. These models have undergone a number of refinements that allow deeper understanding of the circuitry involved in initiating drug seeking and relapse. Notably, the demonstrable involvement of classic corticostriatal habit circuitry and the engagement of prefrontal cortical circuits in extinction training may have relevance to the therapeutic modulation of habit circuitry and drug addiction in humans.
成瘾领域的动物模型被认为是现有的最佳神经精神疾病模型之一。这些模型已经历了多次改进，从而能够更深入地了解引发药物寻求和复发的神经回路。值得注意的是，经典皮质纹状体习惯回路的明显参与以及前额叶皮质回路在消退训练中的参与，可能与人类习惯回路和药物成瘾的治疗调节有关。
