神经生物学的异同。

Similarities and Differences in Neurobiology.

机构信息

Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.

National Institute on Drug Dependence, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing, 100191, China.

出版信息

Adv Exp Med Biol. 2017;1010:45-58. doi: 10.1007/978-981-10-5562-1_3.

DOI:10.1007/978-981-10-5562-1_3

PMID:29098667

Abstract

Substance addiction is a chronic, relapsing brain disease characterized by compulsive drug seeking and use despite harmful consequences. Non-substance addiction is defined recently that people may compulsively engage in an activity despite any negative consequences to their lives. Despite differences with respect to their addictive object, substance addiction and non-substance addiction may share similarities with respect to biological, epidemiological, clinical, genetic and other features. Here we review the similarities and differences in neurobiology between these two addictions with a focus on dopamine, serotonin, opioid, glutamate and norepinephrine systems. Studies suggest the involvement of all these systems in both substance addiction and non-substance addiction while differences may exist with respect to their contributions.

摘要

物质成瘾是一种慢性、复发性的脑部疾病，其特征是尽管存在有害后果，但仍存在强迫性药物寻求和使用。非物质成瘾最近被定义为尽管对生活有任何负面影响，人们仍可能强迫性地从事某项活动。尽管在成瘾对象上存在差异，但物质成瘾和非物质成瘾在生物学、流行病学、临床、遗传和其他特征上可能存在相似之处。在这里，我们重点讨论多巴胺、5-羟色胺、阿片类、谷氨酸和去甲肾上腺素系统，综述了这两种成瘾之间神经生物学的异同。研究表明，所有这些系统都参与了物质成瘾和非物质成瘾，尽管它们的贡献可能存在差异。