Khlystova Z S, Minina T A, Rabotnikova E L, Abdumuratova D A
Morfologiia. 2006;129(1):60-2.
Using histochemical and immunological methods, the development of lymphocyte-tissue complexes in the distal part of human fetal intestine (appendix, Peyer's patch) was studied in relation to the changes taking place in the ileocecal lymph nodes. It was found that this autonomous gut immune system started to function in the second trimester of fetal development. It is dominated by T-cell system of the immunity. After the appearance of meconium in the intestinal lumen, the phenotypical diversity of lymphocytes within the organ was increased, but it did not reach the level found in mature organism. The ileocecal lymph nodes are distinguished by their lymphocyte composition as a T-cell depot in this interorgan and intertissue system, which provides essential homeostasis of the developing fetus.
利用组织化学和免疫学方法，研究了人类胎儿肠道远端（阑尾、派尔集合淋巴结）淋巴细胞 - 组织复合体的发育情况，并将其与回盲部淋巴结的变化相关联。研究发现，这种自主的肠道免疫系统在胎儿发育的第二个月开始发挥作用。它以免疫的T细胞系统为主导。在肠腔内出现胎粪后，器官内淋巴细胞的表型多样性增加，但未达到成熟生物体中的水平。在这个器官间和组织间系统中，回盲部淋巴结以其作为T细胞储存库的淋巴细胞组成而与众不同，这为发育中的胎儿提供了基本的内环境稳定。
