Khlystova Z S, Abdumuratova D A, Savenko V A, Baryshev B B
Vestn Otorinolaringol. 1989 Mar-Apr(2):55-8.
This study was carried out having in view our inadequate knowledge of immunological parameters of human normal tonsils. The purpose of the study was to investigate the development of basic morphological and immunological parameters of organs constituting the functional complex, i. e. palatine, pharyngeal, lingual tonsils and neck lymph nodes that drain them, in human fetuses. Altogether 50 palatine, 31 pharyngeal, 16 lingual tonsils and neck lymph nodes of human fetuses (14 to 32 weeks) were examined. The development and morphology of tonsils as well as the time of lymphocyte settlement were investigated. The pattern of lymphocyte differentiation was studied immunologically. In terms of expression of surface markers, the heterogeneity of T- and B-cell immunity systems and their kinetics in the course of embryogenesis typical of each organ under study were identified. In the complex of organs combined by immune functions, neck lymph nodes can be identified as the pool of T-cells the amount of which makes the total number of the cells in all tonsils. As to B-cells, tonsils contained predominantly EAC-RFC. When compared to tonsils, lymph nodes contained the least quantities of B-lymphocytes.
本研究是鉴于我们对人类正常扁桃体免疫参数的认识不足而开展的。该研究的目的是调查人类胎儿中构成功能复合体的器官，即腭扁桃体、咽扁桃体、舌扁桃体以及引流它们的颈部淋巴结的基本形态学和免疫参数的发育情况。总共检查了50个胎儿（14至32周）的腭扁桃体、31个咽扁桃体、16个舌扁桃体以及颈部淋巴结。研究了扁桃体的发育和形态以及淋巴细胞定居的时间。从免疫学角度研究了淋巴细胞分化模式。根据表面标志物的表达情况，确定了所研究的每个器官在胚胎发生过程中T细胞和B细胞免疫系统的异质性及其动力学。在由免疫功能联合起来的器官复合体中，颈部淋巴结可被视为T细胞库，其数量与所有扁桃体中的细胞总数相当。至于B细胞，扁桃体中主要含有EAC-RFC。与扁桃体相比，淋巴结中B淋巴细胞的数量最少。
