Khlystova Z S, Abdumuratova D A
Arkh Anat Gistol Embriol. 1990 Sep;99(9):73-8.
Investigations of the lymph nodes embryogenesis had mainly an anatomo-histological character. At the present time a new approach is necessary: elucidation of main immunological characteristics of lymphoid elements, occupying lymph nodes already at early stages of ontogenesis. The aim of the investigation was to study marker composition of lymphocytes, occupying the lymph nodes of various regional groups, that are in anatomical and functional connection with the thymus, Waldeyer-Pirogov lympho-epithelial pharyngeal ring, appendix and Peyer's patches. The anterior, mediastinal, ileocecal and deep cervical lymph nodes have been studied in 23 human fetuses 17-28-week-old. Immunological and morphological peculiarities of development have been followed in the groups of the lymph nodes mentioned. According to the expression of superficial markers the character of heterogeneity in T- and B-cell systems and their kinetics during embryogenesis has been stated to be characteristic for each regional group. In all lymph nodes the number of T-lymphocytes predominate, their greatest content is noted in the ileocecal lymph nodes. The B-lymphatic system in the lymph nodes is presented poorly with its predominance among immunoglobulin-positive lymphocytes of Ig M(+)-cells.
对淋巴结胚胎发生的研究主要具有解剖组织学特征。目前需要一种新方法：阐明在个体发育早期就占据淋巴结的淋巴样成分的主要免疫学特征。本研究的目的是研究占据与胸腺、瓦尔代尔 - 皮罗戈夫咽淋巴上皮环、阑尾和派伊尔结存在解剖学和功能联系的不同区域组淋巴结的淋巴细胞的标志物组成。对23例17 - 28周龄的人类胎儿的前纵隔、回盲部和颈深淋巴结进行了研究。对上述淋巴结组发育的免疫学和形态学特性进行了追踪。根据表面标志物的表达情况，已表明T细胞和B细胞系统的异质性特征及其在胚胎发生过程中的动力学在每个区域组中都具有特点。在所有淋巴结中，T淋巴细胞数量占主导，在回盲部淋巴结中其含量最高。淋巴结中的B淋巴细胞系统表现不佳，IgM(+)细胞在免疫球蛋白阳性淋巴细胞中占优势。
