Hunsaker Michael R, Thorup Jessica A, Welch Trent, Kesner Raymond P
Department of Psychology, University of Utah, Salt Lake City, UT 84112, USA.
Behav Neurosci. 2006 Dec;120(6):1252-6. doi: 10.1037/0735-7044.120.6.1252.
The hippocampus mediates associative learning involving spatial and temporal information. Specifically, paired associations in which a trace interval separates the elements appear to be associated within CA1. In contrast, CA3 appears to be involved in associations containing spatial elements. This suggests that CA3, but not CA1, is involved as long as the spatial association does not contain temporal elements; conversely, CA1 is involved when a temporal element is included, regardless of whether there are spatial elements present. In the present study, rats were run on an object-trace-place paired-associate learning paradigm. Rats with CA3 as well as rats with CA1 lesions showed deficits in the acquisition of this task. These results suggest that CA1 is involved in making arbitrary associations involving a temporal (trace) element, whereas CA3 is involved in making associations that involve spatial elements; furthermore, CA1 and CA3 interact in the presence of both spatial and temporal information.
海马体介导涉及空间和时间信息的联想学习。具体而言，在CA1区域内，似乎能将由痕迹间隔分隔元素的配对联想联系起来。相比之下，CA3似乎参与包含空间元素的联想。这表明，只要空间联想不包含时间元素，CA3而非CA1就会参与其中；相反，当包含时间元素时，CA1就会参与，无论是否存在空间元素。在本研究中，让大鼠在物体-痕迹-位置配对联想学习范式下进行实验。CA3损伤的大鼠以及CA1损伤的大鼠在该任务的习得方面均表现出缺陷。这些结果表明，CA1参与形成涉及时间（痕迹）元素的任意联想，而CA3参与形成涉及空间元素的联想；此外，在同时存在空间和时间信息的情况下，CA1和CA3会相互作用。
