Kamens Helen M, Burkhart-Kasch Sue, McKinnon Carrie S, Li Na, Reed Cheryl, Phillips Tamara J
Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health & Science University, OR, USA.
Behav Neurosci. 2006 Dec;120(6):1356-66. doi: 10.1037/0735-7044.120.6.1356.
Acute drug stimulation has been proposed to be an endophenotype for drug abuse. The authors previously reported the short-term selective breeding of lines of mice for low (LMACT) and high (HMACT) stimulation to methamphetamine (MA). These mice were used to examine whether common genes influence the locomotor response to MA and ethanol. Additionally, the authors tested these mice for ethanol drinking, locomotor sensitization, and clearance. LMACT mice were less stimulated by ethanol and consumed more ethanol than HMACT mice, but the lines did not differ in ethanol-induced sensitization. A small difference in ethanol clearance rate (0.1 mg/ml/h) likely had little impact on behavior. Some common genes may influence the locomotor response to MA and ethanol, as well as ethanol drinking.
急性药物刺激已被认为是药物滥用的一种内表型。作者之前报道了对小鼠品系进行短期选择性培育，以获得对甲基苯丙胺（MA）低刺激（LMACT）和高刺激（HMACT）的品系。这些小鼠被用于研究常见基因是否影响对MA和乙醇的运动反应。此外，作者还对这些小鼠进行了乙醇摄入、运动敏化和清除率测试。与HMACT小鼠相比，LMACT小鼠受乙醇刺激较小，但乙醇摄入量更多，不过这两个品系在乙醇诱导的敏化方面没有差异。乙醇清除率的微小差异（0.1毫克/毫升/小时）可能对行为影响不大。一些常见基因可能会影响对MA和乙醇的运动反应以及乙醇摄入。
