Lee Douglas O, Ousley Opal Y
Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
J Child Adolesc Psychopharmacol. 2006 Dec;16(6):737-46. doi: 10.1089/cap.2006.16.737.
The aims of this systematic chart review were to determine the frequency of attention-deficit/hyperactivity disorder (ADHD) in a clinic sample of children and adolescents with autism spectrum disorders (ASD), to compare ADHD symptoms in children with Autistic Disorder, Asperger's Disorder, and pervasive developmental disorders-not otherwise specified (PDD-NOS), to compare ADHD symptoms in individuals with and without ADHD-related chief complaints, and to determine the correlation between ADHD Rating Scale (ADHD RS) scores and age.
This systematic chart review examined data from children and adolescents who were consecutively referred to a university-based autism psychopharmacology program. All individuals were diagnosed by semistructured interview for ASD and ADHD, and ADHD symptoms were assessed using ADHD RS scores.
Of 83 children, 78% fulfilled Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for ADHD and exceeded the 93rd percentile norm for the ADHD RS. Hyperactivity-impulsivity scores were significantly greater in individuals with autism than those with other ASDs. DSM-IV ADHD diagnosis was represented equally in individuals with and without ADHD as their chief complaints. ADHD RS hyperactivity-impulsivity and total scores were negatively correlated with age.
ADHD symptoms are pervasive in clinically referred children and adolescents with ASD.
本系统图表回顾的目的是确定自闭症谱系障碍(ASD)儿童和青少年临床样本中注意力缺陷多动障碍(ADHD)的发生率,比较自闭症障碍、阿斯伯格障碍和未特定的广泛性发育障碍(PDD-NOS)儿童的ADHD症状,比较有和没有ADHD相关主要诉求的个体的ADHD症状,并确定ADHD评定量表(ADHD RS)得分与年龄之间的相关性。
本系统图表回顾检查了连续转诊至一个大学自闭症精神药理学项目的儿童和青少年的数据。所有个体均通过针对ASD和ADHD的半结构化访谈进行诊断,并使用ADHD RS得分评估ADHD症状。
在83名儿童中,78%符合《精神障碍诊断与统计手册》第4版(DSM-IV)ADHD标准,且ADHD RS得分超过第93百分位标准。自闭症个体的多动冲动得分显著高于其他ASD个体。DSM-IV ADHD诊断在以ADHD为主诉和不以ADHD为主诉的个体中比例相同。ADHD RS多动冲动得分和总分与年龄呈负相关。
ADHD症状在临床转诊的患有ASD的儿童和青少年中普遍存在。