Yu Hyeon-Hee, Seo Se-Jeong, Hur Jong-Moon, Lee Heung-Soo, Lee Young-Eun, You Yong-Ouk
Department of Food and Nutrition, Kunsan National University, Kunsan, Republic of Korea.
J Med Food. 2006 Winter;9(4):505-9. doi: 10.1089/jmf.2006.9.505.
Asarum sieboldii has been used in traditional folk medicine to treat dental caries and periodontal disease. In the present study, we investigated the inhibitory effect of the ethanol and aqueous extracts of A. sieboldii on the growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans. The ethanol and aqueous extracts of A. sieboldii inhibited the growth and acid production of S. mutans. In the bacterial adherence assay, the ethanol and aqueous extracts of A. sieboldii significantly lowered the adherence of S. mutans. We also found that the ethanol and aqueous extracts of A. sieboldii significantly inhibited the synthesis of water-insoluble glucan by crude glucosyltransferase. These results suggest that A. sieboldii extracts may inhibit the caries-inducing properties of S. mutans. Further studies are necessary to clarify the active constituents of A. sieboldii extracts responsible for such biomolecular activities.
细辛在传统民间医学中被用于治疗龋齿和牙周疾病。在本研究中，我们调查了细辛乙醇提取物和水提取物对变形链球菌生长、产酸、黏附及水不溶性葡聚糖合成的抑制作用。细辛乙醇提取物和水提取物抑制了变形链球菌的生长和产酸。在细菌黏附试验中，细辛乙醇提取物和水提取物显著降低了变形链球菌的黏附。我们还发现，细辛乙醇提取物和水提取物显著抑制了粗葡糖基转移酶介导的水不溶性葡聚糖的合成。这些结果表明，细辛提取物可能抑制变形链球菌的致龋特性。有必要进一步研究以阐明细辛提取物中负责此类生物分子活性的活性成分。
