McConathy Jonathan, Capello Catherine, Jarkas Nachwa, Stowe Zachary N, Owens Michael J
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Int J Neuropsychopharmacol. 2007 Dec;10(6):759-63. doi: 10.1017/S1461145706007474. Epub 2007 Jan 4.
Obtaining drugs for use in basic and preclinical research has become increasingly difficult and in many instances is dependent upon the company's interest in the proposed research. In this paper, we describe a simple procedure for extracting the antidepressants sertraline, paroxetine, fluoxetine, venlafaxine, citalopram, escitalopram, duloxetine and atomoxetine from their readily available pharmaceutical preparations. With the exception of citalopram, escitalopram and duloxetine in which the free base was the final product, the hydrochloride salt forms of these drugs were prepared. This procedure provides these antidepressants in gram quantities in recovered yields ranging from 53% to 100% at over 99% purity and is in principle applicable to other drugs as well.
获取用于基础研究和临床前研究的药物变得越来越困难，而且在很多情况下取决于公司对拟开展研究的兴趣。在本文中，我们描述了一种从容易获得的药物制剂中提取抗抑郁药舍曲林、帕罗西汀、氟西汀、文拉法辛、西酞普兰、艾司西酞普兰、度洛西汀和托莫西汀的简单方法。除了最终产物为游离碱形式的西酞普兰、艾司西酞普兰和度洛西汀外，制备了这些药物的盐酸盐形式。该方法能以克级量提供这些抗抑郁药，回收率在53%至100%之间，纯度超过99%，并且原则上也适用于其他药物。
