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Ets样蛋白1在人食管鳞状细胞癌中的过表达

Overexpression of Ets-like protein 1 in human esophageal squamous cell carcinoma.

作者信息

Chen An-Guo, Yu Zai-Cheng, Yu Xin-Feng, Cao Wen-Feng, Ding Fang, Liu Zhi-Hua

机构信息

Department of Thoracic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.

出版信息

World J Gastroenterol. 2006 Dec 28;12(48):7859-63. doi: 10.3748/wjg.v12.i48.7859.

Abstract

AIM

To study the expression pattern of Ets-like protein 1 (Elk-1) in human esophageal squamous cell carcinoma (ESCC) and to analyze its relationship with clinicopathologic parameters.

METHODS

The expression of Elk-1 in fresh esophageal cancer tissues and their corresponding normal mucosae was detected immunohistochemically (IHC) by means of tissue microarray (TMA). Its correlation with clinical characteristics was evaluated and analyzed by univariate analysis. All statistical analyses were performed by SPSS version 13.0.

RESULTS

Expression level of transcription factor Elk-1 increased in 78.5% (84/107) ESCC tissues compared with their matched normal esophageal epithelium. However, the expression of Elk-1 did not show any obvious correlation with degree of differentiation of esophageal carcinoma (in well-differentiated, moderately-differentiated and poorly-differentiated tumors, the increased expression was 7/8, 60/74, and 19/25, respectively, P > 0.05). Moreover, no obvious correlation was found with lymph node metastasis and depth of invasion.

CONCLUSION

Increased expression of transcription factor Elk-1 may play an important role in esophageal carcinogenesis.

摘要

目的

研究Ets样蛋白1(Elk-1)在人食管鳞状细胞癌(ESCC)中的表达模式,并分析其与临床病理参数的关系。

方法

通过组织芯片(TMA)采用免疫组织化学(IHC)方法检测新鲜食管癌组织及其相应正常黏膜中Elk-1的表达。通过单因素分析评估并分析其与临床特征的相关性。所有统计分析均使用SPSS 13.0版软件进行。

结果

与配对的正常食管上皮相比,78.5%(84/107)的ESCC组织中转录因子Elk-1的表达水平升高。然而,Elk-1的表达与食管癌的分化程度无明显相关性(在高分化、中分化和低分化肿瘤中,表达增加分别为7/8、60/74和19/25,P>0.05)。此外,与淋巴结转移和浸润深度也无明显相关性。

结论

转录因子Elk-1表达增加可能在食管癌发生中起重要作用。

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