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Tissue microarray of head and neck squamous carcinoma: validation of the methodology for the study of cutaneous fatty acid-binding protein, vascular endothelial growth factor, involucrin and Ki-67.头颈部鳞状细胞癌组织芯片：皮肤脂肪酸结合蛋白、血管内皮生长因子、外皮蛋白和Ki-67研究方法的验证
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Differential expression of the keratin-4, -13, -14, -17 and transglutaminase 3 genes during the development of oral squamous cell carcinoma from leukoplakia.口腔白斑发展为口腔鳞状细胞癌过程中角蛋白-4、-13、-14、-17和转谷氨酰胺酶3基因的差异表达。
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Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma.E-钙黏蛋白、α-连环蛋白、β-连环蛋白、γ-连环蛋白及细胞周期蛋白D1在人食管鳞状细胞癌中的表达的预后及临床病理特征
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Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray.利用cDNA微阵列技术发现食管鳞状细胞癌中下调的与Ca2+相关及分化相关基因。
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Structural basis for the coordinated regulation of transglutaminase 3 by guanine nucleotides and calcium/magnesium.鸟嘌呤核苷酸与钙/镁协同调节转谷氨酰胺酶3的结构基础。
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Identification of 9 genes differentially expressed in head and neck squamous cell carcinoma.头颈部鳞状细胞癌中9个差异表达基因的鉴定
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[Study on the loss of heterozygosity and expression of transglutaminase 3 gene in laryngeal carcinoma].[喉癌中谷氨酰胺转移酶3基因杂合性缺失及表达的研究]
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Beta-catenin expression is altered in human colonic aberrant crypt foci.β-连环蛋白的表达在人类结肠异常隐窝病灶中发生改变。
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Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.转谷氨酰胺酶基因的进化：人类染色体15q15上转谷氨酰胺酶基因簇的鉴定。转谷氨酰胺酶X编码基因及一个新的基因家族成员转谷氨酰胺酶Z的结构。
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Transglutaminase-3, an esophageal cancer-related gene.转谷氨酰胺酶3，一种与食管癌相关的基因。
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新型致癌基因TGM3在人食管鳞状细胞癌中的功能研究

Functional studies of a novel oncogene TGM3 in human esophageal squamous cell carcinoma.

作者信息

Liu Wei, Yu Zai-Cheng, Cao Wen-Feng, Ding Fang, Liu Zhi-Hua

机构信息

Department of Thoracic Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

出版信息

World J Gastroenterol. 2006 Jun 28;12(24):3929-32. doi: 10.3748/wjg.v12.i24.3929.

DOI:10.3748/wjg.v12.i24.3929
PMID:16804985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4087948/
Abstract

AIM

To investigate the role of transglutaminase 3 (TGM3) gene in human esophageal squamous cell carcinoma (ESCC), and analyze its relationship with clinicopathological parameters.

METHODS

Gene expression of TGM3 in fresh esophageal cancer tissues and their corresponding normal mucosas was detected immunohistochemically (IHC) by means of tissue microarray (TMA). Its correlation with clinical characteristics was evaluated and analyzed by univariate analysis. All statistical analyses were performed by SPSS version 10.0.

RESULTS

Expression rate of TGM3 was reduced to 81.8% in ESCC. Expression of TGM3 was significantly inversely correlated with histological grade of esophageal carcinoma (in grade I, II and III tumors, the reduced expression was 4/7, 57/71, and 20/21, respectively, P < 0.05), whereas it had no obvious correlations with lymph node metastasis and depth of invasion.

CONCLUSION

Reduced expression of TGM3 may play an important role in esophageal carcinogenesis.

摘要

目的

探讨转谷氨酰胺酶3（TGM3）基因在人食管鳞状细胞癌（ESCC）中的作用，并分析其与临床病理参数的关系。

方法

采用组织芯片（TMA）免疫组织化学（IHC）方法检测新鲜食管癌组织及其相应正常黏膜中TGM3的基因表达。通过单因素分析评估并分析其与临床特征的相关性。所有统计分析均使用SPSS 10.0版软件进行。

结果

ESCC中TGM3的表达率降至81.8%。TGM3的表达与食管癌的组织学分级呈显著负相关（在I级、II级和III级肿瘤中，表达降低分别为4/7、57/71和20/21，P < 0.05），而与淋巴结转移和浸润深度无明显相关性。

结论

TGM3表达降低可能在食管癌发生中起重要作用。