Demirtürk Neşe, Demirdal Tuna, Toprak Dilek, Altindiş Mustafa, Aktepe Orhan Cem
Department of Infectious Diseases and Clinical Microbiology, Afyon Kocatepe University School of Medicine, Afyon, Turkey.
Turk J Gastroenterol. 2006 Dec;17(4):267-72.
BACKGROUND/AIMS: The aim was to determine the seroprevalence rates for hepatitis B virus and hepatitis C virus and the frequency of hepatitis B core antibody seropositivity alone in residents of a city in Turkey. The subjects visited the Family Medicine Outpatient Clinics of a university hospital in Afyon for routine health checks between January 2002 and January 2004.
A single serum sample was collected from subjects examined. The sera were analyzed by ELISA for hepatitis B surface antigen, hepatitis B surface antibody, anti-HBcIgG and anti-hepatitis C virus. Samples that were HBsAg-positive were also screened for hepatitis B early antigen and antibody. Subjects who were positive for anti-HBcIgG alone were considered to have "isolated anti-HBcIgG positivity".
1320 persons weere screened the rates of positivity for HBsAg, anti- HBs, isolated anti-HBcIgG, and anti-hepatitis C virus were 6.6%, 27.2%, 6.1% and 2.2%, respectively. Eight percent of the 87 HBsAg-positive individuals were HBeAg-positive. Comparison of marker detection rates according to sex and age (younger than 50 years vs 50 years or older) revealed a significantly higher prevalence of HBsAg positivity in males than in females (p=0.02), and a significantly higher prevalence of anti-hepatitis C virus and anti-HBcIgG positivity in the older than in the younger group (p=0.001 and p=0.001, respectively).
According to our results, the rates of hepatitis B virus and hepatitis C virus seropositivities in our region are similar to those reported in recent studies from other parts of Turkey. But these results cannot be extrapolated to all residents of the Afyon area because a random sampling method was not used for statistical analysis. However, they provide a good reference for future studies because of the large number of cases investigated.
背景/目的：本研究旨在确定土耳其某城市居民中乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的血清流行率以及单独乙肝核心抗体血清阳性的频率。2002年1月至2004年1月期间，研究对象前往阿菲永市一家大学医院的家庭医学门诊进行常规健康检查。
采集受检者的一份血清样本。采用酶联免疫吸附测定法（ELISA）检测血清中的乙肝表面抗原（HBsAg）、乙肝表面抗体（抗-HBs）、抗-HBcIgG和抗丙型肝炎病毒抗体。对HBsAg阳性的样本还进行了乙肝e抗原和抗体的筛查。单独抗-HBcIgG阳性的受试者被认为具有“孤立性抗-HBcIgG阳性”。
共筛查了1320人，HBsAg、抗-HBs、孤立性抗-HBcIgG和抗丙型肝炎病毒抗体的阳性率分别为6.6%、27.2%、6.1%和2.2%。87例HBsAg阳性个体中，8%为HBeAg阳性。根据性别和年龄（50岁以下与50岁及以上）比较标志物检测率发现，男性HBsAg阳性率显著高于女性（p=0.02），老年组抗丙型肝炎病毒抗体和抗-HBcIgG阳性率显著高于年轻组（分别为p=0.001和p=0.001）。
根据我们的研究结果，我们地区HBV和HCV血清阳性率与土耳其其他地区近期研究报道的相似。但由于统计分析未采用随机抽样方法，这些结果不能外推至阿菲永地区的所有居民。然而，由于调查的病例数量众多，它们为未来的研究提供了良好的参考。
