Department of Medical Oncology, Dr Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Ankara, Turkey.
Med Oncol. 2012 Sep;29(3):1892-5. doi: 10.1007/s12032-011-9928-6. Epub 2011 Apr 3.
Chronic infections with hepatitis C virus (HCV) are frequently pronounced in the etiology of malignancies especially in hepatocellular carcinoma. The association between HCV and risk of renal cell carcinoma (RCC) development has been stated recently. The authors retrospectively evaluated hepatitis serology for HCV and HBV in patients who had RCC diagnosis between 2005 and 2010 in six oncology centers. Control group was also included from the three different published studies that hepatitis serology studied in healthy people that has been living in the same geographic regions. Histologically confirmed 903 RCC cases and 5,267 healthy subjects were included the study. Median age at diagnosis of RCC was 58 (range: 26-89). There was no increase in HCV positivity in RCC patients compared to healthy control group (1.7 vs. 1.5%; P = 0.77). Frequency of HBsAg positivity was 4.4 and 4.1% in RCC and control groups, respectively (P = 0.65). There is no increase in frequency of HCV and HBsAg positivity in RCC patients. HCV positivity in RCC patients were not different from the healthy people.
慢性丙型肝炎病毒（HCV）感染常与恶性肿瘤的发病机制有关，尤其是肝细胞癌。最近有研究表明 HCV 与肾细胞癌（RCC）发生风险之间存在关联。作者回顾性评估了 2005 年至 2010 年间在六个肿瘤中心诊断为 RCC 的患者的 HCV 和 HBV 肝炎血清学，并从三个不同的已发表的研究中选取了居住在同一地理区域的健康人群的肝炎血清学研究作为对照组。该研究共纳入了 903 例组织学确诊的 RCC 病例和 5267 例健康对照。RCC 患者的中位年龄为 58 岁（范围：26-89 岁）。与健康对照组相比，RCC 患者的 HCV 阳性率并没有增加（1.7%比 1.5%；P=0.77）。RCC 和对照组患者的 HBsAg 阳性率分别为 4.4%和 4.1%（P=0.65）。RCC 患者的 HCV 和 HBsAg 阳性率并没有增加。RCC 患者的 HCV 阳性率与健康人群没有差异。
