Jensen K, Tuxen C, Pedersen-Bjergaard U, Jansen I
Department of Neurology, Gentofte Hospital, Hellerup, Denmark.
Cephalalgia. 1991 Sep;11(4):175-82. doi: 10.1046/j.1468-2982.1991.1104175.x.
The algesic effect of substance-P with and without the addition of bradykinin or 5-hydroxytryptamine was studied in 13 healthy volunteers. Test substances dissolved in saline were injected into the temporal muscle and the forearm skin and the effects compared with those of saline. In the temporal muscle, none of the test substances induced more pain than saline, but substance-P with bradykinin lowered the pressure pain threshold by 18% (p less than 0.02). All test substances induced pain wheal and flare in the forearm skin. Substance-P induced a more pronounced flare reaction than bradykinin, whereas the latter induced more pain than substance-P. This dissociation between pain and flare may indicate that C-fibres in the human skin represent more than one type of nociceptor.
在13名健康志愿者身上研究了P物质在添加或不添加缓激肽或5-羟色胺的情况下的致痛作用。将溶解于生理盐水的测试物质注射到颞肌和前臂皮肤中，并将其效果与生理盐水的效果进行比较。在颞肌中，没有一种测试物质比生理盐水诱发更多疼痛，但P物质与缓激肽一起使压力痛阈值降低了18%（p<0.02）。所有测试物质在前臂皮肤中均诱发了疼痛性风团和红晕。P物质诱发的红晕反应比缓激肽更明显，而缓激肽诱发的疼痛比P物质更强烈。这种疼痛与红晕之间的分离可能表明，人类皮肤中的C纤维代表不止一种类型的伤害感受器。
