Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei 115, Taiwan.
Int J Mol Sci. 2019 Mar 30;20(7):1596. doi: 10.3390/ijms20071596.
Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception. Here, we review studies of SP-mediated nociception and anti-nociception in terms of peptide features, SP-modulated ion channels, and differential effector systems underlying neurokinin 1 receptors (NK1Rs) in differential cell types to elucidate the effect of SP and further our understanding of SP in anti-nociception. Most importantly, understanding the anti-nociceptive SP-NK1R pathway would provide new insights for analgesic drug development.
P 物质（SP）是一种 11 个氨基酸的神经肽，长期以来一直被认为是疼痛的效应物。然而，越来越多的研究提出了 SP 在抗伤害感受中的矛盾作用。在这里，我们根据肽特征、SP 调节的离子通道以及神经激肽 1 受体（NK1R）在不同细胞类型中的差异效应系统，综述了 SP 介导的伤害感受和抗伤害感受的研究，以阐明 SP 的作用，并进一步了解 SP 在抗伤害感受中的作用。最重要的是，了解抗伤害感受的 SP-NK1R 途径将为开发镇痛药物提供新的见解。
