Medvedev A I, Revina G I
Radiobiologiia. 1991 Sep-Oct;31(5):728-32.
Acid polypeptides, synthetic analogues of a natural modifier of lethal effect of radiation, were shown to inhibit double-strand DNA breaks (DSB) repair, to increase irreparable DSB accumulation and to enhance the formation of structural chromosome rearrangements in gamma-irradiated mammalian cells. The authors discuss the possibility of involvement of proteins, that contain amino acid sequences comparable, in length, with a modifier, into radiation formation of irreparable DSB.
酸性多肽是辐射致死效应天然调节剂的合成类似物，已表明其可抑制双链DNA断裂（DSB）修复，增加不可修复的DSB积累，并增强γ射线照射的哺乳动物细胞中染色体结构重排的形成。作者讨论了含有与调节剂长度相当的氨基酸序列的蛋白质参与不可修复DSB辐射形成的可能性。
