[Effect of 8-bromoadenine on DNA repair].

Effects of 8-bromoadenine have been investigated on the prereplicative and post-replicative processes of DNA repair in gamma-irradiated monolayer HeLa-M cells, a method of ultracentrifugation in alkaline sucrose gradients being used. A 30-90 minutes treatment of cells with 8-bromoadenine before irradiation (1, 5, 20 krad) distinctly inhibits the DNA single-strand break repair. The molecular weight of DNA, synthesized in gamma-irradiated cells in the presence of 8-bromoadenine, is less than that synthesized without 8-bromoadenine.