硫喹诺菌素铁载体的生物合成：硫转移的一种有趣变体。
Biosynthesis of the thioquinolobactin siderophore: an interesting variation on sulfur transfer.
作者信息
Godert Amy M, Jin Mi, McLafferty Fred W, Begley Tadhg P
机构信息
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
出版信息
J Bacteriol. 2007 Apr;189(7):2941-4. doi: 10.1128/JB.01200-06. Epub 2007 Jan 5.
Abstract
The thioquinolobactin siderophore from Pseudomonas fluorescens ATCC 17400 utilizes a variation of the sulfur transfer chemistry found in thiamine and molydobterin biosynthesis. A JAMM motif protein cleaves the C-terminal amino acid residues following a diglycine moiety on a small sulfur carrier protein, and the modified C terminus is activated and sulfurylated, forming a thiocarboxylate.
摘要
来自荧光假单胞菌ATCC 17400的硫喹诺洛菌素铁载体利用了硫胺素和钼蝶呤生物合成中发现的硫转移化学的变体。一种具有JAMM基序的蛋白质切割小硫载体蛋白上双甘氨酸部分后的C末端氨基酸残基，修饰后的C末端被激活并硫酰化，形成硫代羧酸盐。
相似文献
1
Biosynthesis of the thioquinolobactin siderophore: an interesting variation on sulfur transfer.硫喹诺菌素铁载体的生物合成：硫转移的一种有趣变体。
J Bacteriol. 2007 Apr;189(7):2941-4. doi: 10.1128/JB.01200-06. Epub 2007 Jan 5.
2
Thioquinolobactin, a Pseudomonas siderophore with antifungal and anti-Pythium activity.硫喹诺洛菌素，一种具有抗真菌和抗腐霉活性的假单胞菌铁载体。
Environ Microbiol. 2007 Feb;9(2):425-34. doi: 10.1111/j.1462-2920.2006.01154.x.
3
The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein ThiS.硫胺素噻唑磷酸部分的生物合成：由硫载体蛋白ThiS介导的硫转移
Chem Biol. 2004 Oct;11(10):1373-81. doi: 10.1016/j.chembiol.2004.08.009.
4
[Utilization by Escherichia coli and Pseudomonas fluorescens of a siderophore from Pseudomonas fluorescens strain PAB].[荧光假单胞菌菌株PAB产生的一种铁载体被大肠杆菌和荧光假单胞菌的利用情况]
Rev Argent Microbiol. 1992 Apr-Jun;24(2):60-6.
5
The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway.铜绿假单胞菌铁载体喹诺菌素由犬尿氨酸途径的中间体黄尿酸合成。
Mol Microbiol. 2004 Apr;52(2):371-84. doi: 10.1111/j.1365-2958.2004.03999.x.
6
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis.结核分枝杆菌中新半胱氨酸生物合成途径的重建。
J Am Chem Soc. 2005 Aug 24;127(33):11602-3. doi: 10.1021/ja053476x.
7
Iron metabolism in Pseudomonas: salicylic acid, a siderophore of Pseudomonas fluorescens CHAO.假单胞菌中的铁代谢：水杨酸，荧光假单胞菌CHAO的一种铁载体。
Biofactors. 1992 Dec;4(1):23-7.
8
Role of conserved cysteines in mediating sulfur transfer from IscS to IscU.保守半胱氨酸在介导硫从IscS转移至IscU过程中的作用。
FEBS Lett. 2005 Sep 26;579(23):5236-40. doi: 10.1016/j.febslet.2005.08.046.
9
Regulation of alkaline metalloprotease promoter by N-acyl homoserine lactone quorum sensing in Pseudomonas fluorescens.荧光假单胞菌中N-酰基高丝氨酸内酯群体感应对碱性金属蛋白酶启动子的调控
J Appl Microbiol. 2007 Dec;103(6):2174-84. doi: 10.1111/j.1365-2672.2007.03488.x.
10
Analysis of the draft genome of Pseudomonas fluorescens ATCC17400 indicates a capacity to take up iron from a wide range of sources, including different exogenous pyoverdines.荧光假单胞菌ATCC17400基因组草图分析表明，其具有从多种来源摄取铁的能力，包括不同的外源性绿脓菌素。
Biometals. 2014 Aug;27(4):633-44. doi: 10.1007/s10534-014-9734-7. Epub 2014 Apr 23.
引用本文的文献
1
Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis.含酰基亚磺酸的天然产物磺烯菌素的发现及其生物合成特性研究
Nat Chem. 2025 May 20. doi: 10.1038/s41557-025-01833-9.
2
Discovery of a novel methionine biosynthetic route -phospho-l-homoserine.发现了一种新的甲硫氨酸生物合成途径——磷酸-l-高丝氨酸。
Appl Environ Microbiol. 2024 Oct 23;90(10):e0124724. doi: 10.1128/aem.01247-24. Epub 2024 Sep 23.
3
Sulfur incorporation into biomolecules: recent advances.硫在生物分子中的掺入：最新进展。
Crit Rev Biochem Mol Biol. 2022 Oct-Dec;57(5-6):461-476. doi: 10.1080/10409238.2022.2141678. Epub 2022 Nov 20.
4
Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase.酶结构域的共现指导了恶唑酮合酶的发现。
Nat Chem Biol. 2021 Jul;17(7):794-799. doi: 10.1038/s41589-021-00808-4. Epub 2021 Jun 7.
5
Biosynthesis of Sinapigladioside, an Antifungal Isothiocyanate from Burkholderia Symbionts.从 Burkholderia 共生菌合成芥子甘油二葡萄糖苷，一种具有抗真菌作用的异硫氰酸酯。
Chembiochem. 2021 Jun 2;22(11):1920-1924. doi: 10.1002/cbic.202100089. Epub 2021 May 4.
6
Biosynthesis of thiocarboxylic acid-containing natural products.含硫羧酸类天然产物的生物合成。
Nat Commun. 2018 Jun 18;9(1):2362. doi: 10.1038/s41467-018-04747-y.
7
Biosynthesis of antibiotic chuangxinmycin from .由……合成抗生素创新霉素 。
你提供的原文似乎不完整，“from”后面缺少具体内容。
Acta Pharm Sin B. 2018 Mar;8(2):283-294. doi: 10.1016/j.apsb.2017.07.005. Epub 2017 Aug 12.
8
A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals.一场三环马戏：三种蛋白质原性芳香族氨基酸的代谢及其在动植物健康中的作用
Front Mol Biosci. 2018 Apr 6;5:29. doi: 10.3389/fmolb.2018.00029. eCollection 2018.
9
Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis.综述：麦角硫因和卵硫醇的生物合成，天然产物生物合成中前所未有的转硫策略
Biochemistry. 2018 Jun 19;57(24):3309-3325. doi: 10.1021/acs.biochem.8b00239. Epub 2018 Apr 6.
10
Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029.来自天蓝色链霉菌SB12029的含硫抗菌平板霉素及其类似物。
Bioorg Med Chem. 2016 Dec 15;24(24):6348-6353. doi: 10.1016/j.bmc.2016.04.026. Epub 2016 Apr 13.
本文引用的文献
1
Consecutive ion activation for top down mass spectrometry: improved protein sequencing by nozzle-skimmer dissociation.自上而下质谱分析的连续离子激活：通过喷嘴-分离器解离改进蛋白质测序
Anal Chem. 2005 Sep 15;77(18):5777-84. doi: 10.1021/ac0580215.
2
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis.结核分枝杆菌中新半胱氨酸生物合成途径的重建。
J Am Chem Soc. 2005 Aug 24;127(33):11602-3. doi: 10.1021/ja053476x.
3
Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry.人类钼辅因子的生物合成：通过质谱法鉴定MOCS3类硫氧还蛋白结构域中的过硫化物基团。
Biochemistry. 2005 May 31;44(21):7912-20. doi: 10.1021/bi0503448.
4
The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein ThiS.硫胺素噻唑磷酸部分的生物合成：由硫载体蛋白ThiS介导的硫转移
Chem Biol. 2004 Oct;11(10):1373-81. doi: 10.1016/j.chembiol.2004.08.009.
5
The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway.铜绿假单胞菌铁载体喹诺菌素由犬尿氨酸途径的中间体黄尿酸合成。
Mol Microbiol. 2004 Apr;52(2):371-84. doi: 10.1111/j.1365-2958.2004.03999.x.
6
JAMM: a metalloprotease-like zinc site in the proteasome and signalosome.JAMM：蛋白酶体和信号体中类似金属蛋白酶的锌位点。
PLoS Biol. 2004 Jan;2(1):E2. doi: 10.1371/journal.pbio.0020002. Epub 2003 Nov 24.
7
NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.烟酰胺腺嘌呤二核苷酸（NAD）生物合成：细菌中色氨酸到喹啉酸途径的鉴定
Chem Biol. 2003 Dec;10(12):1195-204. doi: 10.1016/j.chembiol.2003.11.011.
8
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).硫胺素焦磷酸（维生素B1）噻唑部分的生物合成。
Biochemistry. 2003 Oct 28;42(42):12430-8. doi: 10.1021/bi034902z.
9
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.大肠杆菌钼蝶呤合酶的机制和突变研究阐明了钼蝶呤生物合成的最后一步。
J Biol Chem. 2003 Apr 18;278(16):14523-32. doi: 10.1074/jbc.M300453200. Epub 2003 Feb 5.
10
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.Rpn11金属蛋白酶在26S蛋白酶体的去泛素化和降解过程中的作用。
Science. 2002 Oct 18;298(5593):611-5. doi: 10.1126/science.1075898. Epub 2002 Aug 15.
Zotero 插件