缺铁对大鼠肝脏酶的影响。
The effects of iron deficiency on rat liver enzymes.
作者信息
Bailey-Wood R, Blayney L M, Muir J R, Jacobs A
出版信息
Br J Exp Pathol. 1975 Jun;56(3):193-8.
Abstract
The effect of iron deficiency on a number or iron containing enzymes in rat liver has been examined. In addition, 6-phosphogluconate dehydrogenase and glucose 6-phosphate dehydrogenase have been assayed. Of the mitochondrial electron transport reactions only succinate-cytochrome C reductase activity was decreased in iron deficient animals. Microsomal reductase enzymes associated with the NADPH-oxidase system were also markedly decreased although cytochrome P450 concentrations were unaffected. Both 6-phosphogluconate dehydrogenase and glucose 6-phosphate dehydrogenase were reduced in young iron deficient rats but the former had returned to control levels at the age of 14 weeks.
摘要
研究了缺铁对大鼠肝脏中多种含铁酶的影响。此外，还测定了6-磷酸葡萄糖酸脱氢酶和葡萄糖6-磷酸脱氢酶。在缺铁动物中，线粒体电子传递反应中只有琥珀酸-细胞色素C还原酶活性降低。与NADPH氧化酶系统相关的微粒体还原酶也明显降低，尽管细胞色素P450浓度未受影响。在缺铁幼鼠中，6-磷酸葡萄糖酸脱氢酶和葡萄糖6-磷酸脱氢酶均降低，但前者在14周龄时已恢复到对照水平。
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