Adam P, Haralambieva E, Ott G
Institut für Pathologie, Julius-Maximilians-Universität Würzburg.
Pathologe. 2007 Feb;28(1):6-14. doi: 10.1007/s00292-006-0887-1.
Extranodal marginal zone B-cell lymphomas of the MALT type constitute, with around 8% of all B-cell lymphomas, the third most frequent lymphoma in the Western hemisphere. Their unifying characteristic principle is their origin in organs that are typically devoid of a regular lymphatic parenchyma ("primary" MALT). In contrast, "secondary" MALT is acquired in these sites by chronic inflammatory processes triggered by chronic infections or autoimmune diseases. The organotypic characteristics of these particular lymphoid tumours are also mirrored by organ-specific precursor lesions and in tumour biology. Usually, MALT-type lymphomas remain confined to their site of origin for a long time, disseminating only late during the course of the disease. Hence, they may be controlled by local treatment (excision, irradiation). Moreover, the distinctive genetic constitution of MALT-type lymphomas, although varying from organ to organ, indicates particular transformation pathways obviously related to the specific precursor lesion and, hence, of organ-specific quality.
黏膜相关淋巴组织（MALT）型结外边缘区B细胞淋巴瘤约占所有B细胞淋巴瘤的8%，是西半球第三常见的淋巴瘤。它们统一的特征性原则是起源于通常缺乏规则淋巴实质的器官（“原发性”MALT）。相比之下，“继发性”MALT是由慢性感染或自身免疫性疾病引发的慢性炎症过程在这些部位获得的。这些特殊淋巴肿瘤的器官特异性特征也反映在器官特异性前驱病变和肿瘤生物学中。通常，MALT型淋巴瘤在很长一段时间内局限于其起源部位，仅在疾病过程后期才发生播散。因此，它们可以通过局部治疗（切除、放疗）得到控制。此外，MALT型淋巴瘤独特的基因构成，尽管因器官不同而有所差异，但显示出明显与特定前驱病变相关的特定转化途径，因此具有器官特异性。
