Kalpadakis Christina, Pangalis Gerassimos A, Vassilakopoulos Theodoros P, Kyriakaki Stavroula, Yiakoumis Xanthi, Sachanas Sotirios, Moschogiannis Maria, Tsirkinidis Pantelis, Korkolopoulou Penelope, Papadaki Helen A, Angelopoulou Maria K
Department of Haematology, Heraklion University Hospital, University of Crete, POBOX 1352, Heraklion, Crete, Greece,
Curr Hematol Malig Rep. 2014 Sep;9(3):262-72. doi: 10.1007/s11899-014-0218-1.
Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) is an indolent lymphoma arising in extranodal sites. Several infectious agents and autoimmune disorders have been implicated in its pathogenesis. The stomach represents the most common and best-studied organ involved by MALT lymphoma and its development is strongly associated with Helicobacter pylori (Hp) infection. MALT lymphomas are characterized by an indolent clinical course and excellent survival in most cases, independently of the treatment delivered. Recent progress in the knowledge of the etiology and the cellular and molecular pathological events related to MALT lymphomas allowed us to improve our clinical understanding of this disease entity and to better define treatment strategies.
黏膜相关淋巴组织（MALT）结外边缘区淋巴瘤是一种发生于结外部位的惰性淋巴瘤。多种感染因子和自身免疫性疾病与其发病机制有关。胃是MALT淋巴瘤最常见且研究最充分的受累器官，其发生与幽门螺杆菌（Hp）感染密切相关。MALT淋巴瘤的特点是临床病程惰性，多数情况下预后良好，与所采用的治疗方法无关。近年来，在MALT淋巴瘤的病因以及相关细胞和分子病理事件方面的研究进展，使我们对这一疾病实体有了更深入的临床认识，并能更好地制定治疗策略。
