Evans Ellen M, Racette Susan B, Van Pelt Rachael E, Peterson Linda R, Villareal Dennis T
Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Menopause. 2007 May-Jun;14(3 Pt 1):481-8. doi: 10.1097/01.gme.0000243570.78570.f7.
The aim of this study was to assess the independent and additive effects of soy protein isolate (SPI) and moderate-intensity exercise (EX) on bone turnover and bone mineral density (BMD).
This study used a placebo-controlled, double-blind (soy), randomized 2 (SPI vs milk protein isolate [MPI]) x 2 (EX vs no EX) design. Sixty-one postmenopausal women were randomized, and 43 (62 +/- 5 y) completed the 9-month intervention (SPI, n = 10; MPI, n = 12; SPI + EX, n = 11; MPI + EX, n = 10). Serum C-terminal cross-linked telopeptides of type I collagen and serum bone-specific alkaline phosphatase were measured as markers of bone resorption and formation, respectively. BMD was measured by dual-energy x-ray absorptiometry.
At 9 months, SPI reduced serum C-terminal cross-linked telopeptides (-13.3% +/- 15.3% vs -1.5% +/- 21.0%; P = 0.02) and serum bone-specific alkaline phosphatase (-4.7% +/- 14.7% vs 6.5% +/- 17.7%; P = 0.02) compared to milk protein isolate. EX attenuated the reduction in serum C-terminal cross-linked telopeptides (-1.9% +/- 21.6% vs -12.4% +/- 15.3%; P = 0.04); however, no EX effects were apparent in serum bone-specific alkaline phosphatase at 9 months (2.8% +/- 16.1% vs -1.0% +/- 18.3%; P = 0.28). Neither SPI nor EX affected BMD at any site; however, change in BMD was related to change in fat mass (r = 0.40, P < 0.05).
In postmenopausal women (1) SPI reduces bone turnover with no impact on BMD over 9 months; (2) moderate-intensity endurance exercise training did not favorably alter bone turnover and had no impact on BMD; and (3) there were no additive effects of soy and exercise on bone turnover or BMD.
本研究旨在评估大豆分离蛋白（SPI）和中等强度运动（EX）对骨转换和骨密度（BMD）的独立及相加作用。
本研究采用安慰剂对照、双盲（大豆）、随机2（SPI与乳清分离蛋白[MPI]）×2（运动与不运动）设计。61名绝经后女性被随机分组，43名（62±5岁）完成了为期9个月的干预（SPI组，n = 10；MPI组，n = 12；SPI +运动组，n = 11；MPI +运动组，n = 10）。分别测定血清I型胶原C端交联肽和血清骨特异性碱性磷酸酶作为骨吸收和形成的标志物。采用双能X线吸收法测量骨密度。
9个月时，与乳清分离蛋白相比，SPI降低了血清I型胶原C端交联肽（-13.3%±15.3%对-1.5%±21.0%；P = 0.02）和血清骨特异性碱性磷酸酶（-4.7%±14.7%对6.5%±17.7%；P = 0.02）。运动减弱了血清I型胶原C端交联肽的降低幅度（-1.9%±21.6%对-12.4%±15.3%；P = 0.04）；然而，9个月时运动对血清骨特异性碱性磷酸酶无明显影响（2.8%±16.1%对-1.0%±18.3%；P = 0.28）。SPI和运动均未影响任何部位的骨密度；然而，骨密度的变化与脂肪量的变化相关（r = 0.40，P < 0.05）。
在绝经后女性中，（1）SPI可降低骨转换，在9个月内对骨密度无影响；（2）中等强度耐力运动训练未对骨转换产生有益改变，对骨密度也无影响；（3）大豆和运动对骨转换或骨密度无相加作用。
