Alibés Andreu, Yankilevich Patricio, Cañada Andrés, Díaz-Uriarte Ramón
Structural Biology and Biocomputing Programme, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029, Madrid, Spain.
BMC Bioinformatics. 2007 Jan 10;8:9. doi: 10.1186/1471-2105-8-9.
Researchers involved in the annotation of large numbers of gene, clone or protein identifiers are usually required to perform a one-by-one conversion for each identifier. When the field of research is one such as microarray experiments, this number may be around 30,000.
To help researchers map accession numbers and identifiers among clones, genes, proteins and chromosomal positions, we have designed and developed IDconverter and IDClight. They are two user-friendly, freely available web server applications that also provide additional functional information by mapping the identifiers on to pathways, Gene Ontology terms, and literature references. Both tools are high-throughput oriented and include identifiers for the most common genomic databases. These tools have been compared to other similar tools, showing that they are among the fastest and the most up-to-date.
These tools provide a fast and intuitive way of enriching the information coming out of high-throughput experiments like microarrays. They can be valuable both to wet-lab researchers and to bioinformaticians.
参与大量基因、克隆或蛋白质标识符注释的研究人员通常需要对每个标识符进行一对一的转换。当研究领域是诸如微阵列实验之类时,这个数字可能在30000左右。
为帮助研究人员在克隆、基因、蛋白质和染色体位置之间映射登录号和标识符,我们设计并开发了IDconverter和IDClight。它们是两个用户友好的、免费的网络服务器应用程序,还通过将标识符映射到通路、基因本体术语和文献参考上来提供额外的功能信息。这两个工具都面向高通量,并且包含最常见基因组数据库的标识符。已将这些工具与其他类似工具进行了比较,结果表明它们是速度最快且最新的工具之一。
这些工具提供了一种快速且直观的方式来丰富来自微阵列等高通量实验的信息。它们对湿实验室研究人员和生物信息学家都可能有价值。