Khatri Purvesh, Sellamuthu Sivakumar, Malhotra Pooja, Amin Kashyap, Done Arina, Draghici Sorin
Department of Computer Science, Wayne State University, 431 State Hall, Detroit, MI 48202, USA.
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W762-5. doi: 10.1093/nar/gki472.
The Onto-Tools suite is composed of an annotation database and six seamlessly integrated, web-accessible data mining tools: Onto-Express, Onto-Compare, Onto-Design, Onto-Translate, Onto-Miner and Pathway-Express. The Onto-Tools database has been expanded to include various types of data from 12 new databases. Our database now integrates different types of genomic data from 19 sequence, gene, protein and annotation databases. Additionally, our database is also expanded to include complete Gene Ontology (GO) annotations. Using the enhanced database and GO annotations, Onto-Express now allows functional profiling for 24 organisms and supports 17 different types of input IDs. Onto-Translate is also enhanced to fully utilize the capabilities of the new Onto-Tools database with an ultimate goal of providing the users with a non-redundant and complete mapping from any type of identification system to any other type. Currently, Onto-Translate allows arbitrary mappings between 29 types of IDs. Pathway-Express is a new tool that helps the users find the most interesting pathways for their input list of genes. Onto-Tools are freely available at http://vortex.cs.wayne.edu/Projects.html.
Onto-Tools套件由一个注释数据库和六个无缝集成的、可通过网络访问的数据挖掘工具组成：Onto-Express、Onto-Compare、Onto-Design、Onto-Translate、Onto-Miner和Pathway-Express。Onto-Tools数据库已得到扩展，纳入了来自12个新数据库的各类数据。我们的数据库现在整合了来自19个序列、基因、蛋白质和注释数据库的不同类型的基因组数据。此外，我们的数据库还扩展到包括完整的基因本体（GO）注释。利用增强后的数据库和GO注释，Onto-Express现在允许对24种生物体进行功能分析，并支持17种不同类型的输入ID。Onto-Translate也得到了增强，以充分利用新的Onto-Tools数据库的功能，最终目标是为用户提供从任何类型的识别系统到任何其他类型的无冗余且完整的映射。目前，Onto-Translate允许在29种类型的ID之间进行任意映射。Pathway-Express是一个新工具，可帮助用户为其输入的基因列表找到最有趣的途径。Onto-Tools可在http://vortex.cs.wayne.edu/Projects.html上免费获取。
