急性早幼粒细胞白血病的小鼠模型

Mouse models of acute promyelocytic leukemia.

作者信息

Kogan S C

机构信息

Department of Laboratory Medicine and Comprehensive Cancer Center, University of California, San Francisco, Room S-864, 513 Parnassus Avenue, San Francisco, CA 94143-0100, USA.

出版信息

Curr Top Microbiol Immunol. 2007;313:3-29. doi: 10.1007/978-3-540-34594-7_2.

DOI:10.1007/978-3-540-34594-7_2

PMID:17217036

Abstract

Mouse models of acute promyelocytic leukemia have been generated through transgenic, knock-in, retroviral, and xenograft strategies. These models have been used to elucidate mechanisms underlying leukemogenesis. Among the areas investigated are the role of reciprocal fusions; effects of target cells, expression levels, and mouse strains; cooperating events; and restrictive and permissive factors. These models have also been used to gain insight into the effects of the immune system on leukemic cells and the mechanism of response to retinoic acid. Furthermore, preclinical studies utilizing these mice have advanced therapy for myeloid leukemia.

摘要

急性早幼粒细胞白血病的小鼠模型已通过转基因、基因敲入、逆转录病毒和异种移植策略构建出来。这些模型已被用于阐明白血病发生的潜在机制。研究领域包括相互融合的作用；靶细胞、表达水平和小鼠品系的影响；协同事件；以及限制性和许可性因素。这些模型还被用于深入了解免疫系统对白血病细胞的影响以及对维甲酸反应的机制。此外，利用这些小鼠进行的临床前研究推动了髓系白血病的治疗进展。