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Pharmacogenetics: it's not just about ivermectin in collies.

作者信息

Dowling Patricia

机构信息

Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan.

出版信息

Can Vet J. 2006 Dec;47(12):1165-8.

PMID:17217086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1636591/
Abstract
摘要

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本文引用的文献

1
Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation.一只患有多药耐药基因1（MDR1）突变的柯利犬对地高辛和美西律的敏感性
J Vet Intern Med. 2006 Mar-Apr;20(2):415-7. doi: 10.1892/0891-6640(2006)20[415:damsia]2.0.co;2.
2
Therapeutic implications of the MDR-1 gene.多药耐药基因1（MDR-1）的治疗意义
J Vet Pharmacol Ther. 2004 Oct;27(5):257-64. doi: 10.1111/j.1365-2885.2004.00607.x.
3
Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.犬类多药耐药基因1-1Δ（mdr1-1Delta）的品种分布与历史，这是一种药物遗传学突变，标志着柯利犬系品种的出现。
Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11725-30. doi: 10.1073/pnas.0402374101. Epub 2004 Aug 2.
4
Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity.一只患有与伊维菌素敏感性相关的MDR1缺失突变的犬中，P-糖蛋白底物化疗药物的毒性增加。
J Am Vet Med Assoc. 2003 Nov 15;223(10):1453-5, 1434. doi: 10.2460/javma.2003.223.1453.
5
Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.柯利犬对伊维菌素的敏感性与mdr1基因的缺失突变有关。
Pharmacogenetics. 2001 Nov;11(8):727-33. doi: 10.1097/00008571-200111000-00012.
6
Loperamide poisoning in the dog.犬洛哌丁胺中毒
Vet Hum Toxicol. 1996 Feb;38(1):31-3.
7
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.小鼠多药耐药蛋白1a（mdr1a）P-糖蛋白基因的破坏导致血脑屏障缺陷，并增加对药物的敏感性。
Cell. 1994 May 20;77(4):491-502. doi: 10.1016/0092-8674(94)90212-7.