Mealey Katrina L, Meurs Kathryn M
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA.
J Am Vet Med Assoc. 2008 Sep 15;233(6):921-4. doi: 10.2460/javma.233.6.921.
To evaluate the breed distribution of the ABCB1-1Delta polymorphism in a large number of dogs in North America, including dogs of several herding breeds in which this polymorphism has been detected and other breeds in which this polymorphism has not yet been identified.
Cross-sectional study.
5,368 dogs from which buccal swab samples were collected for purposes of ABCB1 genotyping.
From May 1, 2004, to September 30, 2007, DNA specimens derived from buccal swab samples collected from 5,368 dogs underwent ABCB1 genotyping. These data were reviewed, and results for each dog were recorded in a spreadsheet, along with the dog's breed. The genotypes for each breed were tallied by use of a sorting function.
The ABCB1-1Delta allele was identified in 9 breeds of dogs and in many mixed-breed dogs. Breeds that had the ABCB1-1Delta allele included Collie, Longhaired Whippet, Australian Shepherd (standard and miniature), Shetland Sheepdog, Old English Sheepdog, Border Collie, Silken Windhound, and German Shepherd Dog (a breed in which this mutation had not been detected previously).
The ABCB1-1Delta polymorphism is associated with increased susceptibility to many adverse drug reactions and with suppression of the hypothalamic-pituitary-adrenal axis and is present in many herding breeds of dog. Veterinarians should be familiar with the breeds that have the ABCB1-1Delta polymorphism to make appropriate pharmacologic choices for these patients.
评估北美大量犬类中ABCB1 - 1Delta多态性的品种分布情况，包括已检测到该多态性的几种畜牧品种犬以及尚未鉴定出该多态性的其他品种犬。
横断面研究。
5368只犬，采集其颊拭子样本用于ABCB1基因分型。
从2004年5月1日至2007年9月30日，对从5368只犬采集的颊拭子样本所提取的DNA标本进行ABCB1基因分型。对这些数据进行审查，并将每只犬的结果连同其品种记录在电子表格中。使用分类功能统计每个品种的基因型。
在9个品种的犬以及许多混种犬中鉴定出ABCB1 - 1Delta等位基因。具有ABCB1 - 1Delta等位基因的品种包括柯利犬、长毛惠比特犬、澳大利亚牧羊犬（标准型和迷你型）、设得兰牧羊犬、古代英国牧羊犬、边境牧羊犬、丝毛猎风犬和德国牧羊犬（该品种此前未检测到这种突变）。
ABCB1 - 1Delta多态性与许多药物不良反应易感性增加以及下丘脑 - 垂体 - 肾上腺轴抑制有关，并且存在于许多畜牧品种犬中。兽医应熟悉具有ABCB1 - 1Delta多态性的品种，以便为这些患者做出合适的药物选择。
