Liao C H, Lai C C, Ding L W, Hou S M, Chiu H C, Chang S C, Hsueh P R
Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei, Taiwan.
Int J Tuberc Lung Dis. 2007 Jan;11(1):96-102.
A medical centre in Taipei, Taiwan.
To investigate the trend and characteristics of patients with non-tuberculous mycobacteria (NTM) related skin and soft tissue infection.
A total of 63 patients with culture-proven diseases were identified from January 1997 to December 2004. The medical records of all patients were reviewed.
Twenty-seven patients were infected with rapidly growing mycobacteria (RGM), 19 with Mycobacterium marinum, six with M. avium complex (MAC), five with M. kansasii and six with other species. Most patients presented with a protracted cutaneous lesion without systemic symptoms, and two thirds of the patients had a history of exposure. Seventy-three per cent of the lesions involved the extremities. Underlying illness with suppressed immunity was documented in 30.2% of the patients, and was most prevalent in patients with MAC (100%) and M. kansasii (60%). Of the patients, 62% underwent at least one surgical intervention, and 77.8% received treatment with different antimicrobial combinations. Most patients (86%) recovered completely. Granulomatous inflammation was found in 88.9% of biopsied tissue associated with M. marinum infection, 31.8% with RGM and 25.0% with MAC.
A combination of surgery and antimicrobials cured most patients with microbiologically proven localised NTM skin and soft tissue infection.
台湾台北的一家医疗中心。
调查非结核分枝杆菌（NTM）相关皮肤和软组织感染患者的趋势和特征。
1997年1月至2004年12月共确定了63例经培养证实患病的患者。对所有患者的病历进行了回顾。
27例患者感染快速生长分枝杆菌（RGM），19例感染海分枝杆菌，6例感染鸟分枝杆菌复合群（MAC），5例感染堪萨斯分枝杆菌，6例感染其他菌种。大多数患者表现为持续性皮肤病变且无全身症状，三分之二的患者有接触史。73%的病变累及四肢。30.2%的患者有免疫抑制的基础疾病，在MAC患者（100%）和堪萨斯分枝杆菌患者（60%）中最为常见。62%的患者至少接受了一次手术干预，77.8%的患者接受了不同抗菌药物联合治疗。大多数患者（86%）完全康复。在与海分枝杆菌感染相关的活检组织中，88.9%发现肉芽肿性炎症，RGM感染为31.8%，MAC感染为25.0%。
手术和抗菌药物联合治愈了大多数经微生物学证实的局限性NTM皮肤和软组织感染患者。
