Gage F H, Kawaja M D, Fisher L J
Dept of Neurosciences, University of California, San Diego, La Jolla 92093-0624.
Trends Neurosci. 1991 Aug;14(8):328-33. doi: 10.1016/0166-2236(91)90156-o.
Grafting cells to the CNS is a useful approach to address fundamental and clinical issues in neurobiology. Recently, a hybrid technique - the genetic modification of cells followed by intracerebral implantation - has emerged, which may potentially enhance the power of CNS grafting. However, several methodological considerations need to be addressed to test the reliability of this new approach. Progress in the gene transfer-grafting technique has implications for expanding the range of issues and problems that may be addressed in both the basic science and clinical arenas.
将细胞移植到中枢神经系统是解决神经生物学中基础和临床问题的一种有用方法。最近，一种混合技术——对细胞进行基因改造后进行脑内植入——已经出现，这可能会增强中枢神经系统移植的效力。然而，为了测试这种新方法的可靠性，需要考虑几个方法学问题。基因转移-移植技术的进展对于扩大基础科学和临床领域中可能解决的问题范围具有重要意义。
